SPECIAL FOCUS: Upper ExtremityHealing of the rotator cuff affecting the biologic and mechanical environmentChaudhury, Salma; Rodeo, Scott A.Author Information Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY Financial Disclosure: No funding was received to support this manuscript. Dr. Rodeo is a paid consultant for Smith and Nephew Richards and he holds stock in Cayenne Medical. Dr. Chaudhury has no financial relationships. The authors declare no conflicts of interest. Correspondence to Scott A. Rodeo, MD, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 Tel: +212 606 1513; fax: +212 249 2373; e-mail: email@example.com Current Orthopaedic Practice: January/February 2012 - Volume 23 - Issue 1 - p 18-22 doi: 10.1097/BCO.0b013e3182410e91 Buy Metrics Abstract Increasing interest in biological and tissue engineering approaches to improving rotator cuff healing has been motivated by the relatively high failure rates after rotator cuff repairs. A number of recent studies have offered improved understanding of the pathophysiologic processes that contribute to the development of rotator cuff tears and have identified a number of treatment targets. While a number of in-vitro and animal studies have reported promising results for enhancing rotator cuff healing, few studies have demonstrated clinical efficacy. Optimizing the dose, timing and delivery method for therapies to modulate the biological or mechanical environment of the rotator cuff may be the key determinant of ultimate clinical success. © 2012 Lippincott Williams & Wilkins, Inc.