REVIEW ARTICLESChondrocyte cell-based techniques for cartilage defect repair do we need cell cultivation? A review of the current status and proposition for further method developmentSchüttler, Stefana; Andjelkov, NenadbAuthor Information aSpecialistcentrum Scandinavia, Eskilstuna, Sweden; Center for Clinical Research Västmanland Regional Hospital Västerås, Sweden bDepartment of Orthopaedics and Center for Clinical Research, Västmanland Regional Hospital Västerås, Sweden The authors have no financial disclosures pertaining to this work or otherwise. Correspondence to Nenad Andjelkov, MD, PhD, Department of Orthopaedics, Västmanland Regional Hospital, Västerås, Sweden Tel: +462 1173000; fax: +462 1175290; e-mail: [email protected]; [email protected] Current Orthopaedic Practice: July/August 2011 - Volume 22 - Issue 4 - p 339-343 doi: 10.1097/BCO.0b013e31821f65b4 Buy Metrics Abstract A critical analysis and review were performed regarding chondrocyte cell-based techniques using cultured chondrocytes. The rationale for use of these methods was analyzed from the level of cultured chondrocyte cell biology to the level of clinical improvement and compared with operative techniques that are not chondrocyte cell-based. No superior results in comparison to non-chondrocyte cell-based techniques was detected. No evidence on a cell biology level was shown to support the use of these cells in focal cartilage repair procedures. Despite superior histological results reported in some studies, the patients did not have better clinical results after surgery. There is no sufficient data at present that show better results when using chondrocyte cell-based techniques for cartilage repair in comparison to non-chondrocyte cell based techniques, such as microfracture and periosteal transplantation. The use of chondrocyte cell-based techniques in their present form is then questionable because of the time consuming process of cell culturing, resources required, and higher risk that such a two-step procedure has to the patient. A proposition for a modified approach has been given in this article. © 2011 Lippincott Williams & Wilkins, Inc.