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VTE prophylaxis after total joint arthroplasty: current challenges—potential solutions

Huo, Michael H.

doi: 10.1097/BCO.0b013e31820ded17

Venous thromboembolism is the most common complication after total hip and total knee arthroplasty and is associated with significant morbidity, potential mortality and increased healthcare costs. However, venous thromboembolism is a preventable complication. This brief review discusses the epidemiology and the economic and clinical impact of venous thromboembolism after total hip or total knee arthroplasty. It also focuses on preventive strategies, such as appropriate prophylaxis, adherence to evidence-based guidelines, and the potential effect of newer pharmacologic agents that are in clinical development.

Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX

The author would like to acknowledge Ruth Sussman, who provided editorial support, with funding from Ortho-McNeil Janssen Scientific Affairs. The author has nothing else to declare.

Correspondence to Michael H. Huo, MD, UT Southwestern Medical School, 1801 Inwood Road, Dallas, TX 75390 Tel: +1 214 645 3335; fax: +1 214 645 3340; e-mail:

© 2011 Lippincott Williams & Wilkins, Inc.