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Venmans Ben J.W. M.D. Ph.D.; van Boxem, A. J.M. M.D., Ph.D.; Smit, Egbert F. M.D., Ph.D.; Postmus, Pieter E. M.D., Ph.D.; Sutedja, Tom G. M.D., Ph.D.
Journal of Bronchology: April 2000


The purpose of the study was to examine the clinically relevant findings that were obtained only by autofluorescence bronchoscopy and not by white-light bronchoscopy. Data from patients at risk for lung cancer who underwent both white-light bronchoscopy and autofluorescence bronchoscopy were analyzed on a per-patient and on a per-bronchoscopy base. Clinically relevant findings were defined as follows: (1) histologic examination of bronchial biopsy specimen showing moderate dysplasia, severe dysplasia, or carcinoma in situ; (2) assessment by the bronchoscopist that the bronchial area to be treated endoscopically was better visualized by autofluorescence bronchoscopy, which was of influence on the treatment. A total of 224 bronchoscopies were performed in 114 patients. Endobronchial therapy was performed during 26 of these bronchoscopies. Clinical relevant findings resulted from 28 autofluorescence bronchoscopies in 18 patients. Twenty-five of 101 intraepithelial neoplastic lesions were detected by autofluorescence bronchoscopy alone during 18 bronchoscopies in 14 patients. During 10 bronchoscopies in 9 patients, autofluorescence bronchoscopy resulted in a better visualization of the extent of endobronchial spread of tumor, which subsequently was treated with endobronchial therapy. We concluded that by adding autofluorescence bronchoscopy to white-light bronchoscopy, clinically relevant information was obtained in 13% (28 of 223) of the bronchoscopies and in 16% (18 of 114) of the patients.

Journal of Bronchology7:118-121, 2000.

Address reprint requests to Dr. Tom G. Sutedja, Department of Pulmonary Medicine. University Hospital Vrije Universiteit. P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

© 2000 Lippincott Williams & Wilkins, Inc.