Focused Clinical ReviewTransbronchial Cryobiopsy in Interstitial Lung Diseases State-of-the-Art Review for the Interventional PulmonologistAvasarala, Sameer K. MD*; Wells, Athol U. MD, PhD†; Colby, Thomas V. MD‡; Maldonado, Fabien MD, FCCP*Author Information *Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN †Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College London, London, UK ‡Department of Pathology, Mayo Clinic, Scottsdale, AZ Disclosure: F.M. is a consult for Erbe Elektromedizin GmbH. The remaining authors there is no conflict of interest or other disclosures. Reprints: Sameer K. Avasarala, MD, T-1218 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 (e-mail: [email protected]). Journal of Bronchology & Interventional Pulmonology: January 2021 - Volume 28 - Issue 1 - p 81-92 doi: 10.1097/LBR.0000000000000716 Buy Metrics Abstract Interstitial lung diseases are a heterogenous group of disorders that are often difficult to diagnose precisely. Clinical, laboratory, radiographic, and histologic information may be needed to arrive at the correct diagnosis. The multidisciplinary discussion has been proven to be useful in this patient group. Transbronchial cryobiopsy has become a popular method for obtaining tissue samples. Over the course of the last decade, there has been a significant amount of research assessing the feasibility, safety, and diagnostic endpoints of transbronchial cryobiopsy in patients with interstitial lung disease. Data continues to mount to support its use, which has been reflected in guidelines and expert panel reports. Patient selection, procedural performance, and appropriate specimen handling are critical factors for success. A coordinated approach by pulmonologists with expertise in interstitial lung diseases, interventional pulmonologists, and thoracic pathologists is essential. In this evidence-based narrative review, we address transbronchial cryobiopsies from these three distinct perspectives. In addition, the current literature was used to address nine common procedural questions. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.