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Effects of Bronchoscopic Lung Volume Reduction Coil Treatment on Arterial Blood Gases

Gülsen, Askin, MD

Journal of Bronchology & Interventional Pulmonology: April 2019 - Volume 26 - Issue 2 - p 90–95
doi: 10.1097/LBR.0000000000000529
Original Investigations

Background: Bronchoscopic lung volume reduction (BLVR) coil treatment is an increasingly used treatment modality for selected severe emphysema patients in recent years. Emphysema causes dynamic hyperinflation, loss of elastic recoil, air trapping, and decreased exercise capacity in advanced stages. This process progresses over time, leading to hypoxic and hypercapnic respiratory failure. The goal of this study is to elucidate the effects of BLVR coil treatment on arterial blood gas parameters in severe emphysema patients with respiratory failure.

Methods: This is a retrospective study performed at a single pneumology center in Turkey. In total, this study included 39 patients diagnosed with severe emphysema who underwent bilateral BLVR coil treatment according to the general inclusion and exclusion criteria in the literature. The patients baseline and 12-month data were collected from medical records.

Results: Twelve months after BLVR coil treatment, significant improvements were observed in patients’ pulmonary function tests, an increase in partial pressure of oxygen in arterial blood (PaO2) from 58.05±9.36 to 73.82±13.3 (P<0.000) and decrease in partial pressure of carbon dioxide in arterial blood (PaCO2) of hypercapnic patients (from 51.60±4.1 to 46.55±6.6 mm Hg; P=0.001).

Conclusion: BLVR coil treatment is reliable and effective in emphysema patients who have hypoxic or mild hypercapnic respiratory failure. Besides improving lung function, BLVR coil treatment can significantly increase PaO2 and decrease PaCO2 in the medium term.

Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research, Center North (ARCN), Borstel, Germany

A.G.: study concept and design, data collection, analysis and interpretation of data, manuscript preparation, and drafting of the manuscript.

Disclosure: There is no conflict of interest or other disclosures.

Reprints: Askin Gülsen, MD, Research Center Borstel, Leibniz Lung Center, Parkallee 35, Borstel 23845, Germany (e-mail:

Received March 19, 2018

Accepted May 29, 2018

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