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Aoki Noriaki M.D.; Soma, Kazui M.D.; Sekine, Toru M.D.; Beck, Robert J. M.D.; Ohwada, Takashi M.D.
Journal of Bronchology: April 2000


Lactate dehydrogenase (LDH) in the bronchoalveolar lavage fluid (BALF) of patients with acute respiratory distress syndrome (ARDS) was investigated to evaluate its potential as an indicator of lung injury. Twelve samples from six patients with ARDS and seven samples from five control patients were studied. Bronchoalveolar lavage was performed to measure the percentage of polymorphonuclear leukocytes, albumin, LDH concentration, and its isoenzyme in BALF. In ARDS patients, the percentage of polymorphonuclear leukocytes, albumin, and LDH concentrations in BALF proved to be significantly higher than in control subjects (p < 0.05). The level of BALF-LDH isoenzyme 4 and 5 was higher than that of the other isoenzymes, and both 4 and 5 isoenzymes showed significant negative correlations with the Pao2/Fio2 ratio (r = −0.730, and r = −0.759, respectively). The total activity of LDH and isoenzymes in BALF might reflect the extent of pulmonary cellular damage after decreased pulmonary oxygenation. Further investigation with a large number of patients will be needed to clarify the clinical usefulness of LDH isoenzyme in BALF.

Journal of Bronchology7:122-126, 2000.

ARDS, acute respiratory distress syndrome; PMNs, polymorphonuclear leukocytes; BALF, bronchoalveolar lavage fluid; LDH, lactate dehydrogenase; BAL, bronchoalveolar lavage; P/F ratio, ratio of Pao2 to Fio2; ANOVA, analysis of variance

Address reprint requests to Dr. Noriaki Aoki, Information Technology, HAM/TMC Jesse Jones Library, 1133 M.D. Anderson Blvd., Houston, TX 77030.

© 2000 Lippincott Williams & Wilkins, Inc.