Snyder Linda S. M.D.; Helmers, Richard A. M.D.Journal of Bronchology: April 1996 Brief Report: PDF Only Free Abstract Pulmonary manifestations of coccidioidomycosis may present with insignificant clinical symptoms and a variety of radiographic abnormalities including patchy infiltrates with or without hilar adenopathy or thin-walled cavities. Coast-to-coast travel is common and many patients are exposed to Coccidioides immitis while traveling or visiting in endemic areas. They are then at risk to manifest coccidioidomycosis when they return to nonendemic parts of the country. This report describes five patients with radiographic findings suggestive of bronchogenic cancer who were subsequently documented to have coccidioidomycosis. These cases highlight two unusual radiographic features of coccidioidomycosis—irregular or enlarging lung masses and significant mediastinal/hilar adenopathy that can mimic bronchogenic cancer. These cases emphasize the crucial importance of obtaining a travel history and the need for invasive testing to secure a diagnosis of coccidioidomycosis in this situation. © Williams & Wilkins 1996. All Rights Reserved.