Original articleShort-term effects of transcatheter aortic valve replacement on blood pressure and cardiac function in elderly patients with severe aortic stenosisAoyama, Riea,b; Takeda, Kazuhirob; Ishikawa, Jojib; Harada, Kazumasab Author Information aDivision of Cardiology, Heart and Vascular Institute, Funabashi Municipal Medical Center, Chiba bDepartment of Cardiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan Received 16 August 2022 Accepted 29 September 2022. Correspondence to Rie Aoyama, MD, PhD, Division of Cardiology, Heart and Vascular Institute, Funabashi Municipal Medical Center, 1-21-1 Kanasugi, Funabashi Chiba, 273-8588 Japan, Tel: +81 47 438 3321; fax: +81 47 439-0737; e-mail: [email protected] Blood Pressure Monitoring ():10.1097/MBP.0000000000000631, December 27, 2022. | DOI: 10.1097/MBP.0000000000000631 Buy PAP Metrics Abstract Background Transcatheter aortic valve replacement (TAVR) is a standard treatment for elderly and high-risk patients with aortic valve stenosis (AS); however, its short-term effects on blood pressure (BP) and cardiac function are not clear. Therefore, we aimed to determine the short-term effects of TAVR in elderly patients (>75 years), who reflect the clinical situation in Japan. Method and results Twenty-eight consecutive elderly patients with severe AS and hypertension who underwent TAVR under general anesthesia were retrospectively investigated. All patients had hypertension that was well controlled with antihypertensive drugs. Serum brain natriuretic peptide level and peak velocity in the aortic valve were significantly reduced. TAVR induces an increase in BP that requires additional antihypertensive agents. There was no correlation between the change rate of SBP and stroke volume index (SVI), but there was a positive correlation between the rate of change in pulse pressure (PP) and SVI. This tendency was particularly observed in patients with low brachial-ankle pulse wave velocity (baPWV). Conclusion We observed post-TAVR hypertension and required additional antihypertensive drugs. The increases in SVI and PP after TAVR resulted in post-TAVR hypertension. Moreover, post-TAVR hypertension is less likely to occur in elderly patients with a high baPWV, which indicates advanced arteriosclerosis. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.