Clinical Methods and PathophysiologyRelation between nocturnal decline in blood pressure and choroidal thickness: a comparative analysis in dipper vs. non-dipper hypertensive patientsTas, Sedata; Altinisik, Muhammedb; Tas, ÜmmücAuthor Information aCardiology Department, Manisa City Hospital bOphthalmology Department, Manisa Celal Bayar University cCardiology Department, Manisa Akhisar State Hospital, Manisa, Turkey Received 27 May 2020 Accepted 28 October 2020 Correspondence to Sedat Tas, MD, Department of Cardiology Manisa City Hospital, 45040 Manisa, Turkey, Tel: +905052919458; e-mail: [email protected] Blood Pressure Monitoring: June 2021 - Volume 26 - Issue 3 - p 176-182 doi: 10.1097/MBP.0000000000000502 Buy Metrics Abstract Purpose To compare choroidal thickness (ChT) and echocardiographical changes in patients with dipper and non-dipper systemic arterial hypertension (HT). Methods Patients with HT were evaluated in two groups according to the 24-hour ambulatory BP monitoring. Compared to day-time values, those whose night-time SBP decreased ≥10% were defined as dippers, and those whose SBP decreased <10% were defined as non-dippers. Transthoracic echocardiography was conducted in all patients. ChT and central macular thickness were measured with spectral-domain optical coherence tomography. ChT was obtained at the subfoveal, 1500 µm nasal and temporal to the fovea. Results Thirty non-dipper (18 females and 12 males) and 23 dipper (16 females and seven males) hypertensive patients were recruited. Sex distribution and the mean age were similar between the groups (P = 0.472; P = 0.12). Disease duration was longer in the non-dipper group (8 ± 3.39 vs. 4.96 ± 1.19 years, P = 0.001). The non-dipper group had lower ChT in subfoveal and temporal locations (P = 0.02 and 0.03, respectively) and higher left atrial volume index (LAVI) and pulmonary valve maximum flow (PV-max; P < 0.001). The night-time SBP was negatively correlated with ChT (P = 0.048) and positive correlated with LAVI and PV-max (P < 0.05). However those correlations were not significant when were controlled by the possible confounding factors as disease duration, age and gender. Conclusion Non-dipper HT patients may have thinner choroid than dippers due to longer duration of HT and higher ambulatory BP levels. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.