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Ambulatory blood pressure variability increases over a 19-year follow-up in a clinic on a solitary island

Narita, Keisukea,b; Eguchi, Kazuoc; Kario, Kazuomib

doi: 10.1097/MBP.0000000000000343
Clinical Study

Objective This study investigated the changes of ambulatory blood pressure (ABP) profiles on the same participants over a 19-year follow-up.

Participants and methods This is a longitudinal study. We conducted 24-h ABP monitoring at baseline in November 1997 and at follow-up in November 2016 for the same participants who were outpatients in a solitary island clinic. To estimate ambulatory blood pressure variability (ABPV), SD, coefficient of variation, and average real variability of ABP were calculated. ABP levels and ABPV at baseline and follow-up were compared using paired t-test.

Results A total of 35 participants were recruited at follow-up (79.3±6.7 years at follow-up). Mean systolic blood pressure levels in 24-h, daytime, and night-time did not change significantly. However, ABPV of systolic/diastolic blood pressure in 24-h and daytime increased at follow-up compared with baseline (P<0.01 in all variables: SD, coefficient of variation, and average real variability), whereas ABPV in night-time did not change significantly.

Conclusion Our observations suggested that 24-h and daytime ABPV increase with aging in community-dwelling elderly people.

aDepartment of Cardiology, Karatsu Red Cross Hospital, Saga

bDepartment of Medicine, Division of Cardiology, Jichi Medical University School of Medicine, Tochigi

cDepartment of Internal Medicine, Hanyu General Hospital, Saitama, Japan

Correspondence to Keisuke Narita, MD, Department of Cardiology, Karatsu Red Cross Hospital, 2430 Watada, Karatsu 847-8588, Japan Tel/fax: +81 955 725 111; e-mail:

Received March 12, 2018

Received in revised form June 19, 2018

Accepted June 28, 2018

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