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Effects of two contraceptives containing drospirenone on blood pressure in normotensive women: a randomized-controlled trial

de Nadai, Mariane N.a; Nobre, Fernandob; Ferriani, Rui A.a,c; Vieira, Carolina S.a,c

doi: 10.1097/MBP.0000000000000139
Clinical Methods and Pathophysiology

Objective Drospirenone (DRSP) is a progestogen derived from spironolactone with antimineralocorticoid action that seems to exert a favorable effect on blood pressure (BP); however, when associated with ethinylestradiol (EE), this effect does not seem to occur. This study aimed to assess possible differences in BP associated with the use of combined oral contraceptives containing DRSP with different doses of EE.

Materials and methods This open-label parallel-group randomized clinical trial involved women randomized to use either 30 mcg of EE+DRSP (n=22) or 20 mcg of EE+DRSP (n=22). Daytime, nighttime, and 24-h BP were evaluated by ambulatory blood pressure monitoring at the beginning of the trial and 6 months after drug therapy.

Results The groups were similar in terms of demographic characteristics. The mean 24-h systolic blood pressure and diastolic blood pressure (DBP) were similar between the groups before and after treatment (P>0.05). With respect to day and nighttime systolic blood pressure and DBP, no statistically significant difference was observed in BP values between the two groups either before or after treatment, except for the daytime DBP in the 30EE+DRSP group. In this group, a decrease of 2 mmHg (3%) in daytime DBP was observed after 6 months of drug therapy (P=0.04).

Conclusion There was no difference in BP associated with the use of combined oral contraceptives containing DRSP irrespective of the EE dose used.

aDepartment of Gynecology and Obstetrics, Medical School of Ribeirao Preto

bDepartment of Internal Medicine, Medical School of Ribeirao Preto, Cardiology Division, University of São Paulo

cNational Institute of Hormones and Women’s Health, Ribeirão Preto, São Paulo, Brazil

Correspondence to Carolina S. Vieira, MD, PhD, Department of Gynecology and Obstetrics, Medical School of Ribeirao Preto, University of São Paulo, Av. Bandeirantes 3900, Campus Universitário, Ribeirao Preto, São Paulo 14049-900, Brazil Tel: +55 (16) 3602 2804; fax: +55 (16) 3633 0946; e-mail:,

Received February 11, 2015

Received in revised form May 12, 2015

Accepted May 21, 2015

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