The use of low-dose amlodipine has not yet been well established in the elderly. This study therefore aimed to evaluate the efficacy and tolerability of low-dose amlodipine in elderly patients with Joint National Committee VI stage I or II hypertension.
Patients and methods
Sixty-five hypertensive individuals (aged 66.3±5.3 years) received amlodipine 2.5 mg per day for 12 weeks before and after two periods of 4 weeks of placebo. At weeks 0, 12 and 16, patients were submitted to office, 24 h ambulatory blood pressure monitoring and home blood pressure measurement.
Office systolic and diastolic blood pressure showed decreases at weeks 8 (153±17, 90±9 mmHg) and 12 (152±16, 90±9 mmHg) compared with weeks 0 (164±16, 99±6 mmHg) and 16 (162±19, 95±9 mmHg). During ambulatory monitoring, a decrease was observed in the average 24 h systolic and diastolic pressure at week 12 (143±13, 86±7 mmHg) compared with weeks 0 (155±15, 93±6 mmHg) and 16 (152±16, 92±8 mmHg). A daytime and night-time reduction in systolic and diastolic pressure was observed on home blood pressure monitoring at week 12 (146±16/88±8, 144±16/93±8 mmHg) compared with weeks 0 (159±17/94±8, 161±19/93±8 mmHg) and 16 (153±16/93±8, 154±17/92±8 mmHg). Adverse reactions were infrequent.
Amlodipine at a dose of 2.5 mg per day showed efficacy and good tolerability in elderly hypertensives.