Many studies have shown definite but weak correlations between 24 h blood pressure and left ventricular mass in hypertension.
The present study applied an original multivariate analysis of parameters from ambulatory blood pressure monitoring to predict left ventricular mass in hypertension.
Two hundred untreated hypertensive subjects (age = 51 ± 13 years, clinic blood pressure = 163/98 mmHg) had echocardiography and 24 h recording of blood pressure. Data from 102 subjects were used to construct a mathematical model for prediction of left ventricular mass. The remaining 98 subjects were used to validate the model.
The model included age, weight, height, 24 h systolic blood pressure, heart rate over 24 h, standard deviations of systolic blood pressure and of heart rate over 24 h. Using this model, we explained 63% of the variance of left ventricular mass. Moreover, the model was validated for the correlation (r = 0.70) between measured and the estimated left ventricular mass.
Systolic blood pressure, heart rate and their standard deviations over 24 h contribute to left ventricular mass in hypertensive subjects. Thus, it is important to take into account not only blood pressure but also heart rate in clinical studies.