ORIGINAL ARTICLESD-dimer assay in Egyptian patients with Gaucher disease: correlation with bone and lung involvementSherif, Eman Ma; Tantawy, Azza AGa; Adly, Amira AMa; Kader, Hossam Ab; Ismail, Eman ARcAuthor Information aDepartment of Pediatrics, Egypt bDepartment of Radiology, Egypt cDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt Received 20 August, 2010 Revised 17 October, 2010 Accepted 27 October, 2010 Correspondence to Eman A.R. Ismail, MD, 5 Nageb Mahfoz Street, Agouza, 12654 Giza, Egypt Fax: +202 3337 5435; e-mail: [email protected] Blood Coagulation & Fibrinolysis: April 2011 - Volume 22 - Issue 3 - p 176-184 doi: 10.1097/MBC.0b013e3283424809 Buy Metrics Abstract Gaucher disease is the most frequent lysosomal storage disorder. Bone and lung involvement are two major causes of morbidity in this disease. D-dimer is a reliable indicator of active microvascular thrombosis, even in patients without overt hypercoagulation. This study aimed to assess D-dimer levels in Gaucher disease, correlating this marker to clinical characteristics and radiological parameters to investigate its role as a potential predictor for the occurrence and severity of skeletal and pulmonary manifestations. The study population consisted of 56 Egyptian patients with Gaucher disease, 36 had type 1 Gaucher disease (64.3%) and 20 had type 3 Gaucher disease (35.7%). Thirty healthy individuals were enrolled as a control group. D-dimer levels were significantly higher in all patients with Gaucher disease compared with controls (P < 0.001). Patients with type 3 showed significantly higher D-dimer concentrations compared with type 1 (P < 0.001). Pulmonary involvement was present in a significant proportion among type 3 Gaucher patients (P < 0.05), whereas bone changes were present in a higher percentage in type 1 compared with type 3 Gaucher patients. D-dimers were significantly higher in patients with abnormal MRI findings of the long bones and in those with ground glass appearance on high-resolution computerized tomography of the chest compared with patients with normal radiology (P < 0.001). Splenectomized patients displayed significantly higher D-dimer levels compared with nonsplenectomized patients (P < 0.001). Our results suggest that D-dimer is significantly elevated in Gaucher disease, particularly type 3, and may be considered as a potential marker of risk prediction of bone and lung involvement that could be used to monitor treatment response. © 2011 Lippincott Williams & Wilkins, Inc.