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Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control

El-ghoroury, Eman Aa; Raslan, Hala Mb; Badawy, Ehsan Ac; El-Saaid, Gamila Sc; Agybi, Mervat Hc; Siam, Ibrahemb; Salem, Sohair Ic

Blood Coagulation & Fibrinolysis: June 2009 - Volume 20 - Issue 4 - p 248–251
doi: 10.1097/MBC.0b013e3283254549
Original Articles

This study investigated the level of platelet malondialdehyde (MDA) as a marker of oxidative stress and coenzyme Q10 (CoQ10) as an index of antioxidant capacity in patients with type 2 diabetes mellitus and their relation to glycemic control. The study group consisted of 28 patients with type 2 diabetes mellitus (10 men and 18 women) with mean age of 48 ± 2 years. Ten healthy individuals, age and sex matched with the patients, were used as a control group. Laboratory investigations in the form of lipid profile, glycosylated hemoglobin, plasma MDA, platelet MDA and plasma CoQ10 were assessed for all patients and controls. The study revealed that plasma and platelet MDA, as a marker of oxidative stress, were significantly higher in diabetic patients than in controls. The level of CoQ10, as antioxidant capacity, was significantly lower in diabetic patients than in controls. There was a negative correlation between plasma CoQ10 concentrations and glycosylated hemoglobin. Type 2 diabetic patients are at increased risk of oxidative stress manifested by increased plasma MDA as well as platelet MDA and decreased CoQ10, and this oxidative stress increases with poor glycemic control.

aClinical and Chemical Pathology Department, Egypt

bInternal Medicine Department, Egypt

cMedical Biochemistry Department, National Research Center, Cairo, Egypt

Received 12 May, 2008

Revised 13 October, 2008

Accepted 13 October, 2008

Correspondence to Dr Eman A. El-ghoroury, MD, Clinical and Chemical Pathology Department, National Research Center, Cairo, Egypt Tel: +20 222665493; e-mail: elghorouryeman@yahoo.com

© 2009 Lippincott Williams & Wilkins, Inc.