Secondary Logo

Journal Logo

The role of physical medicine and rehabilitation in haemophiliac patients

De la Corte-Rodriguez, Hortensiaa; Rodriguez-Merchan, E. Carlosb

Blood Coagulation & Fibrinolysis: January 2013 - Volume 24 - Issue 1 - p 1–9
doi: 10.1097/MBC.0b013e32835a72f3
REVIEW ARTICLE
Free

Physical medicine and rehabilitation aim to evaluate, diagnose and treat disability in haemophiliac patients, while preventing injury or deterioration. They also aim to maintain the greatest degree of functional capacity and independence in patients with haemophilia, or to return them to that state. Rehabilitation, together with clotting factor replacement therapy, has revolutionized the management of these patients in developed countries and reduced their morbidity/mortality rates. A knowledge of the musculoskeletal signs and symptoms of haemophilia is essential for providing a treatment which is suitable and customized. Physical medicine and rehabilitation techniques, which are based on physical means, are intended to reduce the impact which these injuries and their consequences or sequelae can have on the quality of life of patients with haemophilia. Under ideal haemostatic control conditions (primary prophylaxis), people with haemophilia could achieve good physical condition which will allow them to enjoy both physical activity and a daily life without limitations. Currently, children undergoing primary prophylaxis are quite close to this ideal situation. For these physical activities to be carried out, the safest possible situations must be sought.

aDepartment of Physical Medicine and Rehabilitation

bDepartment of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain

Correspondence to Professor E. Carlos Rodriguez-Merchan, Department of Orthopaedic Surgery, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain. E-mail: ecrmerchan@gmx.es

Received 24 July, 2012

Accepted 14 September, 2012

Back to Top | Article Outline

Introduction

Haemorrhage (bleeding) caused by a congenital deficiency in one of the coagulant factors is the main symptom of haemophilia. Haemorrhages which affect the locomotor apparatus are the principal cause of morbidity in haemophiliac patients. In fact, most of the haemorrhages suffered by haemophiliac patients occur in the locomotor apparatus (joints and muscles). The joints in which haemarthrosis (haemorrhages in joints) most frequently occur are the knees, ankles, elbows, hips and shoulders [1].

Physical medicine and rehabilitation aim to evaluate, diagnose, prevent and treat disability in haemophiliac patients. In other words, they aim to maintain the greatest degree of functional capacity and independence in patients suffering from haemophilia, or to return them to that state.

Physical examination of the locomotor apparatus in a patient with haemophilia requires a complete evaluation of the four limbs and the spine, as well as of any possible biomechanical changes to the feet. Clinical evaluation scoring systems and diagnostic imaging tests are important for establishing the diagnosis and universal interpretation criteria. Historically, radiology has been the most widely used test. However, the fact that there is a substantial delay between haemarthroses occurring and radiological anomalies appearing in the joints, has led to ecography (ultrasonography) and MRI becoming increasingly important [2]. MRI is currently considered the gold standard for diagnostic imaging.

Physical therapies, together with clotting factor replacement therapy, has revolutionized the management of these patients in developed countries and reduced their morbidity/mortality rates. The aims of conservative and rehabilitation treatment are to reduce pain, reduce bleeding, improve joint and muscle function and reduce the impact of the disability [3].

It is also necessary to foster regular physical exercise, as this helps patients to maintain good general physical condition. It has been demonstrated that physical activity is a protective factor against the development of bleeding in muscles and joints, and advances in prophylactic haematological treatment of haemophilia have contributed to this [4]. This article aims to review the musculoskeletal signs and symptoms of haemophilia, their evaluation and their treatment by physical medicine and rehabilitation.

Back to Top | Article Outline

Clinical signs and symptoms of haemophilia in the locomotor apparatus

As mentioned above, haemorrhaging is the main symptom of haemophilia. Of haemorrhages, the most frequent are those which affect the musculoskeletal system. These are the principal cause of morbidity in haemophiliac patients, and have a major impact on their quality of life. The commonest signs and symptoms include intra-articular bleeding (haemarthrosis), synovitis, damage to joint cartilage, subchondral cysts and intra-osseous, muscle bruising and haemophiliac pseudotumours [1].

Back to Top | Article Outline

Haemarthrosis

Intra-articular bleeding (haemarthrosis) is the most important musculoskeletal effect of haemophilia, accounting for 75–85% of all bleeding in patients with haemophilia [5]. In intra-articular bleeding, blood flows from the vessels in the synovial membrane [6]. It has been confirmed that the knee, elbow and ankle are the joints most often affected [7]. Without treatment, any patient with severe haemophilia will suffer haemothrosis starting at 2–5 years of age, and will eventually develop arthropathy (joint damage which is visible to X-ray radiography) in their 20s or 30s [8]. No clinical differences have been found between patients with haemophilia A and B, who, in severe forms of the disease when untreated may suffer up to 30–35 haemarthrosis in 1 year [9]. Early prophylactic treatment (primary prophylaxis) has been shown to improve, but not eliminate, the clinical signs and symptoms mentioned above [10]. Haemophiliac arthropathy (degeneration of the joints), which is the consequence of the repeated extravasation of blood into the joint cavity, has two fundamental characteristics: chronic synovitis and the destruction of the joint cartilage [11]. Haemophiliac arthropathy has both inflammatory and degenerative characteristics. Exposure to minimal quantities of blood may be sufficient to cause joint damage [12].

Back to Top | Article Outline

Synovitis

Synovitis is a proliferative disorder of the joint's synovial tissue. A few hours after blood extravasation occurs, the joint capsule becomes distended and there is an acute inflammatory reaction. Acute cases of haemarthrosis are usually resolved in about a week as a result of the digestive action of the synoviocytes of the synovial membrane, which remove the blood [11]. After repeated haemarthroses, however, the synovial membrane will not be capable of removing all the accumulated blood. In an attempt to do so, it will become hypertrophied, and this will lead to iron being deposited in the synovial membrane, in the form of haemosiderin which has been ingested by phagocytic cells and not eliminated; the iron is involved in the proliferation of synovial cells and vascular cells. The hypertrophy of the synovial membrane and neovascularization of its subintimal layer produce synovial tissue which is inflamed, villous, friable and highly vascularized. This makes it more susceptible to later haemorrhaging given the least stimulus [12]. This is how the vicious circle of haemarthrosis–synovitis–haemarthrosis starts, which will turn acute synovitis into a chronic condition [13]. Clinically, there are several differences between haemarthrosis and haemophilic synovitis, which are summarized in Table 1.

Table 1

Table 1

Back to Top | Article Outline

Damage to cartilage

Damage to joint cartilage seems to take place through two mechanisms. In one mechanism, the cartilage suffers a direct change to the synthesis of proteoglycans, which will end in the apoptosis (death) of the chondrocytes, and in the long term to the destruction or degeneration of the joint [11]. In the other, the action of the enzymes and cytokines produced by the inflammatory cells that have infiltrated the synovial membrane also causes secondary damage to the cartilage of the joint [14].

Back to Top | Article Outline

Subchondral cysts and intra-osseous

When the arthropathy is manifest and visible in radiographs, cysts may appear [15]. These may expand towards the joint (subchondral cyst) or towards the metaphysis (intra-osseous cysts). Other aspects typically found in advanced arthropathy are muscular atrophy (Fig. 1) and the presence of joint deformity (changes to the mechanical axes of limbs) (Fig. 2).

Figure

Figure

Figure

Figure

Back to Top | Article Outline

Muscle bruising and pseudotumours

Muscle bruising is the result of injury to blood vessels in muscle tissue. The haemorrhage is usually related to a trauma or muscle strain, although on other occasions, it is the result of muscle overload. Clinically, these manifest as pain and functional impairment. Muscle bruising in a patient with haemophilia can result in complications such as infection, shortening of the muscle and/or tendon, muscular atrophy, peripheral nerve paralysis, compartment syndrome and even haemophiliac pseudotumours.

Back to Top | Article Outline

Evaluation of musculoskeletal injuries in haemophilia

Doctors specializing in the locomotor apparatus must not only treat the complications in joints but also regularly evaluate their patients, in order to prevent and diagnose possible musculoskeletal problems. For many years, evaluation of the degree of joint damage has been performed using two scoring systems: one based on orthopaedic examination and the other on radiological criteria. Both have been approved by the World Federation of Hemophilia (WFH). Today, the great progress in the treatment of haemophilia has made it necessary to seek new techniques for evaluating joints. The current aim of the multidisciplinary teams attending to patients with haemophilia is to unify the criteria and insist on the importance of both clinical examination and imaging in the early stages of haemophiliac arthropathy.

Back to Top | Article Outline

Methods for clinical evaluation

Physical examination of the locomotor apparatus in patients with haemophilia requires a full evaluation of the four limbs, paying special attention to the range of joint mobility, to muscle strength, to the presence of synovitis, to any joint instability and to the presence of axial deformities, as well as to biomechanical changes to the feet, deviations of the spine or any discrepancy in leg length.

For performing a clinical evaluation, the WFH recommends that the Gilbert (1980) examination protocol be followed. This scores seven items related to the loss of anatomical structure, biomechanical changes and joint deformity [16]. However, this tool is not very sensitive when used for children or those patients at early stages of the disease. Other evaluation protocols have therefore been developed, such as the Manco-Johnson score [17], the Pettersson score [18], the European Paediatric Group (Stockholm scale) [19] and those published by Manco-Johnson et al., which are more precise, the Colorado PE-1 for adults, the Colorado PE-0.5 for children over 7 years of age and the Child PE for children aged between 1 and 6 years [20], and, more recently, the Haemophilia Joint Health Score 2.0 (HJHS) [21]. Table 2 summarizes the comparison of the items and scoring used in the Gilbert and Colorado Joint Health Evaluation scoring systems for haemophiliac patients.

Table 2

Table 2

Back to Top | Article Outline

Diagnostic imaging techniques

Several diagnostic imaging techniques have been used to evaluate changes to the joints of patients with haemophilia. Classically, radiographs have been mostly used. However, the considerable delay between the appearance of haemarthrosis and the detection of radiologically visible anomalies is a problem [2].

Back to Top | Article Outline

Conventional radiographs

This is the method usually used for evaluating the joints of patients with haemophilia, although it does have limitations when it comes to detecting soft tissue damage and synovial hypertrophy. It does, however, have the advantages of easy availability, standard projections and practically instantaneous results. Its use is most appropriate in adult patients with advanced joint disease (Fig. 3) [22]. Several classifications of haemophiliac arthropathy based on radiological findings have been developed. Two evaluation methods were presented in the 1980s: the Arnold and Hilgartner classification developed in the USA [2] and the Pettersson score, which was developed in Europe and has been adopted by the WFH [23]. The Arnold and Hilgartner classification [2], described in 1977, is a progressive measurement scale with five stages, which reflect the sequence of changes to joints, describing the worst findings and limitations, including damage to soft tissue. The Pettersson score, described in 1980 [23], is an additive measurement scale in which the presence of the different radiological findings adds points to determine the stage of the damage found in the joints. It does not, however, include soft issue.

Figure

Figure

Back to Top | Article Outline

Ultrasonography (ecography)

This technique is easily available, is economical, is noninvasive and has no secondary effects. The use of ecography to evaluate joints is particularly appropriate in haemophilia patients in the early stages of the disease, as it can detect bleeding in joints, synovial hypertrophy and cartilage damage [24,25]. It is also the most useful radiological test for diagnosing muscle haematoma. It does not, however, show the inside of the bone.

Back to Top | Article Outline

MRI

This technique has advanced considerably in recent decades as a result of improvements to antennas and pulse sequences, which have provided higher spatial resolution and improved its ability to distinguish between the intra-articular components. It has a high resolution for assessing haemarthrosis, synovial hypertrophy, deposits of haemosiderin, focal cartilage damage, bone damage, subchondral bone and cysts, osseous pseudotumours, muscle bruising and other osteoarticular problems caused by haemophilia. It may also be of use in detecting chronic microhaemorrhages in patients undergoing prophylactic treatment who show no clinical evidence of bleeding [26]. MRI is currently considered the gold standard for the exhaustive study of the joints (Fig. 4). It does, however, present three problems: accessibility, the complexity of the examination and the fact that no consensus has currently been established for evaluating its findings. Several scales have been created for measuring arthropathy using MRI. Nuss et al.[27] developed a progressive MRI scale with four categories, the Denver scale, which gives the highest points to the loss of joint cartilage. In a European multicentre study, Lundin et al.[28] independently developed a European MRI scale for evaluating haemophiliac arthropathy. In 2005, the IPSG's international subgroup of MRI experts (International Prophylaxis Study Group) presented a preliminary scale, which combined the Denver and European scales [29,30].

Figure

Figure

Back to Top | Article Outline

Rehabilitation therapy for musculoskeletal problems caused by haemophilia

Haemophilia is considered to be a haematology-based disease which requires orthopaedic treatment. Current treatment therefore aims to prevent musculoskeletal injuries and maintain the locomotor apparatus in optimal condition. Haematologists, rehabilitation specialists and orthopaedic surgeons all, jointly, have central roles in the diagnostic and therapeutic aspects related to the locomotor apparatus in patients with haemophilia.

It is well established that physical medicine benefits people with haemophilia by protecting the musculoskeletal system from repeated bleeding. Rehabilitation, together with clotting factor replacement therapy, has revolutionized the conservative management of these patients in developed countries and reduced their morbidity/mortality rates. Rehabilitation specialists have several functions when treating patients with haemophilia, which are summarized as follows [31]:

  1. Bleeding and its musculoskeletal consequences should be prevented.
  2. The locomotor apparatus should be maintained in optimal condition in order to prevent acute injuries. Prevention is especially important for children who are undergoing primary prophylaxis with no – or few – haemorrhages. Patients must be encouraged to avoid becoming overweight.
  3. Patients must be educated and encouraged to perform physical activity, in accordance with their age and physical characteristics. They must be advised on the type of exercise, its intensity, duration and frequency and the precautions to be taken into account.
  4. A routine physical examination of the patient should be performed in order to obtain the patient's detailed clinical history. Regular checks on the locomotor apparatus should be performed at least every 6 months during osteoarticular development, and annually for adult patients. This will allow detection of signs that damage and injury is occurring.
  5. Any musculoskeletal damage or injuries should be diagnosed and treated early and effectively, when they appear, in order to prevent consequences and sequelae and thus shorten the time spent in hospital.
  6. An individualized early postoperative treatment should be designed to achieve the maximum functional recovery possible in patients undergoing orthopaedic surgery.
  7. Any consequences and sequelae arising from damage or injuries, which have not been cured, should de detected and treated, for example patients who have lost joint mobility and suffer muscular hypotrophy as a result of joint damage in an advanced state.
  8. Difficulties the patients experience in their daily activities and in participating in society must be handled, so that they maintain the highest possible levels of independence and autonomy.

Despite primary prophylaxis some patients suffer clinical haemorrhages [11]. Medical rehabilitation initially requires a clinical evaluation of the patient's physical state in order to develop a customized therapeutic programme [32].

The objectives of the treatment of damage to the locomotor apparatus are to

  1. alleviate the pain,
  2. recover the range of movement in the joint,
  3. prevent muscle atrophy,
  4. improve muscle power and strength,
  5. recover the proprioception,
  6. prevent sequelae and deformities,
  7. improve the functional abilities,
  8. maintain an appropriate pattern of movement when walking,
  9. reduce the frequency of joint bleeds and
  10. improve the quality of life.

To achieve these, there are several possible treatments, which are summarized in Table 3. The therapy should be continued until the physical and functional objectives proposed have been achieved [6].

Table 3

Table 3

We will now analyse the conservative treatment of the musculoskeletal problems which occur most frequently in people with haemophilia, that is haemarthroses, synovitis, damage to joint cartilage and muscle bruising. The practical and theoretical principles of rehabilitation are equally applicable to both young and adult patients, those with circulating inhibitors and those without.

Back to Top | Article Outline

Treatment of haemarthroses

The first and fundamental treatment is clotting factor replacement therapy. It is known that if the intravenous infusion is performed immediately after the appearance of the first symptoms, or at least during the first 2 h after their onset, the amount of bleeding will be limited [33]. When there is a massive amount of intra-articular blood, arthrocentesis (joint aspiration) must be performed as soon as possible [34]. We must not forget other measures such as immobilization in the functional position for 3–4 days, local cryotherapy and recommendations for avoiding overloading the limb. For example, in the case of a leg, a compression bandage or static splint should be used and walking should be permitted using walking sticks to reduce the load. In addition, oral medication could be used to control pain.

Early, once the bleeding has stopped, a supervised and customized programme of rehabilitation should be prescribed in order to prevent any possible functional sequelae. Once 24 h have passed, isometric exercises can be started and then repeated for short periods. In the case of the knee, mobilization of the kneecap will be necessary in order to prevent any adhesions in the extensor apparatus. Ultrasound or short-wave treatment may be used – always in pulsed form – as well as analgesic electrical stimulation [transcutaneous electrical nerve stimulation (TENS)] to reduce pain [35]. On days following this, assisted kinesitherapy is advisable in order to increase the range of movement in the joint. Concentric and eccentric isotonic exercises should be progressively introduced in order to improve muscle trophism, preferably in the open kinetic chain and then in the closed kinetic chain. Electrical muscle stimulation may also be used, if necessary. Finally, coordination and proprioception exercises are added [35].

Back to Top | Article Outline

Treatment of synovitis

Synovitis must be treated as soon as possible to prevent the appearance of recurrent haemarthrosis [1]. In principle, conservative treatment is recommended, which involves 3–6 months of factor VIII/IX replacement therapy (secondary prophylaxis). However, the inflammatory process of synovitis suggests that it is advisable to combine the conservative treatment with physical therapy. Use of anti-inflammatory drugs (COX-2 inhibitors) is also recommended. Topical NSAIDs provide symptomatic relief and can be applied through massage therapy, iontophoresis and sonophoresis.

Kinesitherapy treatments should also be used with the fundamental objective of maintaining or improving mobility, muscle trophism, proprioception and the pattern of movement. If muscle control is poor, electrical stimulation may be used. Ultrasound and various electrotherapy treatments – always in pulsed form – are considered useful for treating synovitis.

Radiosynovectomy, also known as radiation synovectomy, is advisable if, after 6 months, synovitis persists or haemarthrosis reoccurs despite the replacement and rehabilitation therapy [36]. Today, it seems commonly accepted that radiation synovectomy is the treatment of choice, as it acts directly on the synovial membrane. This consists of an intra-articular injection of a radioactive substance with the aim of stabilizing the synovial membrane of the joint in order to reduce the haemarthroses [37]. Radiation synovectomy is performed using radioactive isotopes; the most commonly used are phosphorus-32 (32P), yttrium-90 (90Y) and rhenium-186 (186Re). These nonsurgical techniques are especially important for patients with circulating inhibitors. Surgical synovectomy (arthroscopic) is only indicated if three consecutive radiation synovectomy treatments, at an interval of 6 months, fail to reduce the frequency of the haemarthroses [8].

Back to Top | Article Outline

Treatment of damage to joint cartilage

We have already mentioned that haemophilic arthropathy includes, in addition to synovitis, damage to the joint cartilage which is visible in radiographs in the form of a reduction of the space in the joint, marginal erosions, subchondral cysts and joint deformity. In addition, haemophilic arthropathy is associated with atrophy and loss of muscle strength [38]. In these cases, the objective of the treatment is to alleviate the pain, improve articular and muscular stability, stabilize the joint, control the alignment of axes, reduce impact when loaded, improve joint function and reduce the impact of the disability [39].

As a conservative treatment, chondroprotective drugs such as chondroitin sulfate or glucosamine sulfate and intra-articular injections of hyaluronic acid and dexamethasone can also be used [3]. However, the role of these drugs is still controversial [40].

Physical therapy implies a multidisciplinary approach which includes physiotherapy, occupational therapy, the use of orthoses, technical aids, adaptations to the home and assistance in integrating into society and work and education [41]. Kinesitherapy, hydro-kinesitherapy, thermotherapy, ultrasonotherapy and electrotherapy techniques [42], all of which must be applied by an experienced therapist, are very useful. The electrotherapy treatments usually include a wide variety of techniques (TENS, interferential, magnetic therapy, laser, etc.) which can be used for the various symptoms of haemophilic arthropathy. The benefits of 30–60 min of physical activity per day are also known.

The orthoses most frequently prescribed for haemophilia patients are elbow, knee and ankle braces to stabilize joints; dynamic stretching orthoses to improve flexion deformities; lifts for patients with legs of different lengths; external or internal wedges to improve the support of the rear part of the foot; and plantar orthoses (inlays or inserts) to reduce the pressure on the metatarsals in cases of excessive pressure on the heads of the metatarsals. For arthropathy of the ankle, it may also be advisable to use protective pads to absorb the impact of the heel and/or orthopaedic shoes designed to hold the ankle better [31].

If the conservative treatment fails or the deformities cannot be reduced, surgery will be necessary. In terms of surgery, in order to alleviate the symptoms of arthropathy, the following may be performed: joint debridement using arthroscopy, alignment osteotomy, whole joint prothesis (knee, hip) and arthrodesis (ankle). In these cases, a specific rehabilitation programme after surgery is indicated.

Back to Top | Article Outline

Treatment of muscle bruising

The initial treatment consists of applying clotting factor replacement therapy, pain medication, rest, ice and placing the limb in an antalgic position during the first 48 h. It is not advisable to aspirate the muscle haematoma. On some occasions, the use of soft traction may be necessary to prevent any shortening of the muscle. TENS and pulsed-mode ultrasound may also be applied. Passive kinesitherapy may be necessary in order to recover the range of movement in the joint. Muscle control exercises will progressively become appropriate, depending on the amount of pain. Isotonic contractions should preferably be performed in the open kinetic chain and then in the closed kinetic chain. Likewise, the work should initially be concentric and then eccentric. Electrical muscle stimulation and hydro-kinesitherapy techniques may be very useful. The therapy must always be complemented with proprioception exercises and exercises to improve limb function. If the clinical symptoms of the haematoma are accompanied by paresis of any peripheral nerve due to compression neuropathy, a treatment must be applied for that injury.

Back to Top | Article Outline

Physical activity recommendations in persons with haemophilia

Under ideal haemostatic control conditions (primary prophylaxis), people with haemophilia can achieve good physical condition which will allow them to enjoy both physical activity and a daily life without limitations. Currently, children undergoing primary prophylaxis are quite close to this ideal situation.

It is known that after submaximal physical exercise, significant changes occur in fibrinogen, factor II and factor VII, that is the clotting parameters improve in patients whether they have severe or mild haemophilia [43]. Additionally, the reduced physical activity of patients with haemophilia is associated with reduced aerobic capacity and weaker muscle strength [44]. Additionally, problems in a given joint lead to lack of use, which will result in muscular hypotrophy and a change in the type of muscle fibre [45]. This weakness in muscles and joint instability increase a patient's vulnerability to mechanical demands, increasing the risk of injury and establishing a damaging vicious circle [46]. Additionally, haemophilia patients with a history of haemarthrosis have biomechanical changes (kinetic and kinematic) to the walking cycle and moderate balance mechanism dysfunctions, which imply a greater risk of falling [35,47]. Physical limitations reduce the load on bones, which may lead to bone demineralization [38].

Medical attitudes to haemophilia patients participating in sports have been very varied and have generally been linked to the different modes of haematological therapy. Until 1970, haemophilia patients were not advised to undertake physical activities. Clinicians’ opinions on physical exercise and sports have been changing, and currently favour these activities [46]. It is certainly known today that patients with haemophilia can and must be motivated to perform physical activities. Additionally, developing good physical condition considerably reduces the risk of spontaneous haemorrhages in joints, brain haemorrhage, cardiopathies, diabetes and high blood pressure. Regular physical activity also assists in maintaining good general physical condition by providing normal musculoskeletal function, which is a factor that protects against bleeding in muscles and joint [3]. Physical exercise and taking part in sports improves not only a patients’ physical well being but also their psychological and emotional state. Although patients with haemophilia still experience psychosocial barriers to physical activity, with the right social environment and medical support, they can be as physically active as healthy people of the same age [48]. This positively influences the perception of patients about their quality of life.

For these physical activities to be carried out, safety conditions must be taken into account. The most important are to ensure at least a minimum level of clotting factor through prophylactic treatment and to have a good knowledge of a patient's physical state in order to select the most suitable sport in each case [4,49].

The factors which contribute to the development of an appropriate physical condition are potency, muscle volume, speed of contraction, endurance and coordination. The factors which influence the choice of sport are the patient's tastes, the ability, previous experience and the attitude of others taking part. It is very important for participants to learn the basic skills of the sport and train habitually with a trainer or coach and with suitable equipment and protection [31].

Recommended sports include walking, cycling and swimming [46]. Others are badminton, bowls, cycling, dancing, fishing, golf, hiking, sailing, table tennis, diving and yoga [50]. High-impact sports, however, which may lead to bleeding, are not advisable. The American Pediatric Society has set out three groups of sports with patients with haemophilia in mind, classifying them as high-risk, medium-risk and low-risk sports. There are, however, some haemophilia patients who play contact sports for years (classified as high risk) and have no incidents of bleeding. In recent years, therefore, new classifications have arisen based on new criteria, which emphasize that the decision on whether or not to take part in a sport depends more on the patient's individual characteristics than on their clinical status. The new parameters used for recommending a sport to a haemophilia patient are summarized in Table 4.

Table 4

Table 4

Some authors have suggested that more studies are needed on the role of physical education in the treatment of patients with clotting disorders [51]. It is also necessary to bear in mind that there are no completely safe sports, as all have their own advantages and disadvantages [46]. Additionally, modern haemophilia therapies will probably broaden the range of possible sports [52].

Back to Top | Article Outline

Conclusion

A knowledge of the musculoskeletal damage caused by haemophilia (haemarthrosis, synovitis, arthropathy and muscle bruising) is essential for providing a suitable and customized treatment. Physical medicine and rehabilitation techniques, which are based on physical means, are intended to reduce the impact which the above-mentioned injuries and their consequences or sequelae can have on the quality of life of patients with haemophilia. Prophylactic haematological treatment makes it possible to advise patients to take part in a sport, provided that certain basic safety conditions are obeyed.

Back to Top | Article Outline

Acknowledgements

Conflicts of interest

The authors have no conflicts of interest.

Back to Top | Article Outline

References

1. Valentino LA, Hakobyan N, Enockson C, Simpson ML, Kakodkar NC, Cong L, Song X. Exploring the biological basis of haemophilic joint disease: experimental studies. Haemophilia 2012; 18:310–318.
2. Arnold WD, Hilgartner MW. Hemophilic arthropathy. Current concepts of pathogenesis and management. J Bone Joint Surg Am 1977; 59:287–305.
3. Rodriguez-Merchan EC. Aspects of current management: orthopaedic surgery in haemophilia. Haemophilia 2012; 18:8–16.
4. Sherlock E, Blake C. Participation in sport by Irish people with haemophilia. Haemophilia 2008; 14 (Suppl 2):82 (abstract 12 PO 80).
5. Heim M, Goshen E, Amit Y, Martinowitz U. Synoviorthesis with radioactive Yttrium in haemophilia: Israel experience. Haemophilia 2001; 7 (Suppl 2):36–39.
6. Beeton K, Cornwell J, Alltree J. Muscle rehabilitation in haemophilia. Haemophilia 1998; 4:532–537.
7. Betsy M, Gilbert MS. Haemophilic haemarthrosis. In: Rodriguez-Merchan E-C, editor. The haemophilic joints: new perspectives. Oxford: Wiley-Blackwell; 2003. pp. 17–19.
8. Rodriguez-Merchan EC, Wiedel JD. General principles and indications of synoviorthesis (medical synovectomy) in haemophilia. Haemophilia 2001; 7 (Suppl 2):6–10.
9. Berntorp E. The treatment of haemophilia, including prophylaxis, constant infusion and DDAVP. Baillieres Clin Haematol 1996; 9:259–271.
10. de la Corte-Rodriguez H, Rodriguez-Merchan EC, Jimenez-Yuste V. Radiosynovectomy in haemophilia: quantification of its effectiveness through the assessment of 10 articular parameters. J Thromb Haemost 2011; 9:928–935.
11. Rodriguez-Merchan EC. Cartilage damage in the haemophilic joints: pathophysiology, diagnosis and management. Blood Coagul Fibrinolysis 2012; 23:179–183.
12. Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R, et al. Prophilaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med 2007; 357:353–444.
13. Hoyer LW. Hemophilia A. N Engl J Med 1994; 330:38–47.
14. Roosendaal G, Lafeber FP. Pathogenesis of haemophilic arthropathy. Haemophilia 2006; 12 (Suppl 3):117–121.
15. Swanton MC. Haemophilic arthropathy in dogs. Lab Invest 1959; 8:1269–1273.
16. Gilbert MS. Prophylaxis: musculoskeletal evaluation. Semin Hematol 1993; 30 (Suppl 2):3–6.
17. Manco-Johnson M, Nuss R, Geraghty S, Kilcoyne R, Funk S. A prophylactic program in the United Sates: experience and issues. In: Berntorp E, Nilsson IM, editors. Prophylactic treatment on haemphilia A and B: current and future perspectives. New York: Science & Medicine; 1994. pp. 52–56.
18. Petterson H. Orthopedic joint evaluation in haemophilia. In: Berntorp E, Nilsson IM, editors. Prophylactic treatment of haemophilia A and B: current and future perspectives. New York: Science & Medicine; 1994. pp. 35–39.
19. Hilgartner MW, Makipernaa A, DiMichele DM. Long-term FEIBA prophylaxis does not prevent progression of existing joint disease. Haemophilia 2003; 9:261–268.
20. Manco-Johnson MJ, Nuss R, Funk S, Murphy J. Joint evaluation instruments for children and adults with haemophilia. Haemophilia 2000; 6:649–657.
21. Feldman BM, Babyn P, Doria AS, Heijnen L, Jacobson J, Kilcoyne R, et al. Proceedings of the International Haemophilia Prophylaxis Study Group Meeting, November 2003, Montreal, PQ, Canada. Haemophilia 2005; 11:58–63.
22. Berntorp E, Gomperts E, Hoots K, Wong WY. The next generation of hemophilia treatment specialists. Semin Thromb Hemost 2006; 32 (Suppl 2):39–42.
23. Pettersson H, Ahlberg A, Nilsson IM. A radiologic classification of hemophilic arthropathy. Clin Orthop Relat Res 1980; 149:153–159.
24. Querol F, Rodriguez-Merchan EC. The role of ultrasonography in the diagnosis of the musculoskeletal problems of haemophilia. Haemophilia 2012; 18:e215–e226.
25. de la Corte-Rodriguez H, Rodriguez-Merchan EC, Jimenez-Yuste V. What patient, joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia? Haemophilia 2011; 17:e990–e998.
26. Doria AS. State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future. Haemophilia 2010; 16 (Suppl 5):107–114.
27. Nuss R, Kilcoyne RF, Geraghty S, Shroyer AL, Rosky JW, Mawhinney S, et al. MRI findings in haemophilic joints treated with radiosynoviorthesis with development of an MRI scale of joint damage. Haemophilia 2000; 6:162–169.
28. Lundin B, Pettersson H, Ljung R. A new magnetic resonance imaging scoring method for assessment of haemophilic arthropathy. Haemophilia 2004; 10:383–389.
29. Doria AS, Babyn PS, Lundin B, Kilcoyne RF, Miller S, Rivard GE, et al. Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group. Haemophilia 2006; 12:503–513.
30. Doria AS, Lundin B, Miller S, Kilcoyne R, Dunn A, Thomas S, et al. Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children. Haemophilia 2008; 14:303–314.
31. Heijnen L. The role of rehabilitation and sports in haemophilia patients with inhibitors. Haemophilia 2008; 14 (Suppl6):45–51.
32. Dauty M, Bresson C, Trossaert M. Application of the isokinetic test to quantify knee muscle strength in haemophiliac patients. Haemophilia 2009; 15:973–975.
33. DiMichele D. Hemophilia 1996. New approach to an old disease. Pediatr Clin North Am 1996; 43:709–736.
34. Jansen NW, Roosendaal G, Lafeber FP. Understanding haemophilic arthropathy: an exploration of current open issues. Br J Haematol 2008; 14:632–640.
35. Stephensen D, Drechsler W, Winter M, Scott O. Comparison of biomechanical gait parameters of young children with haemophilia and those of age-matched peers. Haemophilia 2009; 15:509–518.
36. Rodriguez-Merchan EC, Jimenez-Yuste V, Villar A, Quintana M, Lopez-Cabarcos C, Hernandez-Navarro F. Yttrium-90 synoviorthesis for chronic haemophilic synovitis: Madrid experience. Haemophilia 2001; 7 (Suppl 2):34–35.
37. Heim M, Amit Y, Tiktinsky R, Martinowitz U. Radioactive synoviorthesis. Haemophilia 2006; 12 (Suppl 2):80–90.
38. Hoots WK, Rodriguez N, Boggio L, Valentino LA. Pathogenesis of haemophilic synovitis: clinical aspects. Haemophilia 2007; 13 (Suppl 3):4–9.
39. Hilgartner MW. Current treatment of hemophilic arthropathy. Curr Opin Pediatr 2002; 14:46–49.
40. Rodriguez-Merchan EC. Intra-articular injections of hyaluronic acid (viscosupplementation) in the haemophilic knee. Blood Coagul Fibrinolysis 2012; 23:580–583.
41. Heijnen L, Sohail MT. Rehabilitation. In: Rodriguez-Merchan E-C, Goddard NJ, Lee CA, editors. Musculoskeletal aspects of haemophilia. Oxford: Wiley-Blackwell; 2000. pp. 161–168.
42. Garcia MK, Capusso A, Montans D, Massad E, Battistella LR. Variations of the articular mobility of elbows, knees and ankles in patients with severe haemophilia submitted to free active movimentation in a pool with warm water. Haemophilia 2009; 15:386–389.
43. Koch B, Luban NL, Galioto FM Jr, Rick ME, Goldstein D, Kelleher JF Jr. Changes in coagulation parameters with exercise in patients with classic hemophilia. Am J Hematol 1984; 16:227–233.
44. Falk B, Portal S, Tiktinsky R, Weinstein Y, Constantini N, Martinowitz U. Anaerobic power and muscle strength in young hemophilia patients. Med Sci Sports Exerc 2000; 32:52–57.
45. Zhong H, Roy RR, Siengthai B, Edgerton VR. Effects of inactivity on fiber size and myonuclear number in rat soleus muscle. J Appl Physiol 2005; 99:1494–1499.
46. Gomis M, Querol F, Gallach JE, Gonzalez LM, Aznar JA. Exercise and sport in the treatment of haemophilic patients: a systematic review. Haemophilia 2009; 15:43–54.
47. Fearn M, Hill K, Williams S, Mudge L, Walsh C, McCarthy C, et al. Balance dysfunction in adults with haemophilia. Haemophilia 2010; 16:606–614.
48. Buxbaum NP, Ponce M, Saidi P, Michaels LA. Psychosocial correlates of physical activity in adolescents with haemophilia. Haemophilia 2010; 16:656–661.
49. Seuser A, Boehm P, Kurme A, Schumpe G, Kurnik K. Orthopaedic issues in sport for persons with haemophilia. Haemophilia 2007; 13 (Suppl 2):47–52.
50. Jones T, Buzzard B, Heijnen L. Go for it. Guidance on physical activity and sports for people with haemophilia and related disorders. Montreal: World Federation of Haemophilia; 1998. pp. 16–21.
51. Beltrame L, Sayago M, Almeida J. The influence of sports education on changing behavior of persons with hemophilia and von Willebrand disease. Haemophilia 2008; 14 (Suppl 2):93 (abstract 14 PO 14).
52. Fromme A, Dreeskamp K, Pollmann H, Thorwesten L, Mooren FC, Völker K. Participation in sports and physical activity of haemophilia patients. Haemophilia 2007; 13:323–327.
Keywords:

haemophilia; physical medicine; rehabilitation; treatment

© 2013 Lippincott Williams & Wilkins, Inc.