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Managing oral anticoagulant therapy in patients with mechanical heart valves undergoing elective surgery: results of a survey conducted among Italian physicians

Ageno, Waltera; Garcia, Davidb; Libby, Edwardb; Crowther, Mark Ac

Blood Coagulation & Fibrinolysis: December 2004 - Volume 15 - Issue 8 - p 623-628
ORIGINAL ARTICLES
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The optimal perioperative anticoagulation management in patients on warfarin therapy is poorly defined because of the lack of randomized trials. Because guidelines are heterogeneous, we hypothesized that treatment strategies are not uniform in clinical practice. During the Annual Meeting of the Italian Federation of Anticoagulation Clinics, a questionnaire with four different clinical scenarios was distributed. Two scenarios described the cases of patients with a mechanical heart valve in the mitral position and additional risk factors for systemic embolism, one undergoing major surgery (case 1) and one undergoing minor surgery (case 3). Two scenarios described patients with an aortic mechanical heart valve, one undergoing major surgery (case 2) and one minor surgery (case 4). Different preoperative and postoperative management options were offered. Treatment options for all scenarios were the same. Of the 300 questionnaires distributed, 72 were returned (24%). Outpatient full-dose low molecular weight heparin (LMWH) was the most selected strategy in the preoperative phase. It was chosen by 90.3% of participants in case 3, 87.5% in case 1, 62.5% in case 2, and 52.8% in case 4. In the postoperative phase, full-dose LMWH remained the most selected option for cases 1 (75%) and 3 (70.8%), whereas low-dose LMWH was selected by the majority for cases 2 (50%) and 4 (61.1%).

Even among expert clinicians, the management of perioperative anticoagulation is heterogeneous. In particular, the definition of risk categories and the optimal intensity of antithrombotic drugs remain to be assessed by well-designed prospective studies.

aThrombosis Unit, Department of Internal Medicine, University of Insubria, Varese, Italy, bThrombosis Unit, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA and cThrombosis Unit, Department of Haematology, McMaster University, Hamilton, Canada.

Correspondence and requests for reprints to Walter Ageno, U.O. Medicina Interna, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy. Tel: +39 332 278594; fax: +39 332 278229; e-mail: agewal@yahoo.com

Received 2 March 2004 Revised 13 April 2004 Accepted 15 April 2004

© 2004 Lippincott Williams & Wilkins, Inc.