CASE REPORTSAcquired Bernard–Soulier syndrome and hypodysfibrinogenaemia because of multiple myelomaSehgal, Tushara,b; Altohami, Mohammeda; Lafferty, Nicholasa; Desborough, Michaelc; Boyce, Saraa; Kazmi, Rashida; Jenner, Matthewa Author Information aDepartment of Clinical Hematology, University Hospital Southampton, NHS Foundation Trust, United Kingdom bDepartment of Laboratory Medicine (Hematology), All India Institute of Medical Sciences, New Delhi, India cDepartment of Clinical Hematology, Oxford University Hospitals, United Kingdom Correspondence to Tushar Sehgal, MD, DM, Assistant Professor, Department of Laboratory Medicine (Hematology), All India Institute of Medical Sciences, New Delhi, India Tel: +91 8558843932; e-mail: doct[email protected] Received 5 July, 2021 Revised 14 September, 2021 Accepted 4 November, 2021 Blood Coagulation & Fibrinolysis: March 2022 - Volume 33 - Issue 2 - p 130-133 doi: 10.1097/MBC.0000000000001104 Buy Metrics Abstract We describe a case of a patient with multiple myeloma with initial presentation simulating a bleeding disorder. Detailed coagulation work-up showed hypodysfibrinogenaemia along with a platelet function defect consistent with acquired Bernard–Soulier syndrome (BSS). Multiple plasma exchanges led to significant improvement in his bleeding symptoms. To the best of our knowledge, this is the first described case of simultaneous presentation of hypodysfibrinogenaemia and BSS secondary to multiple myeloma. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.