HAEMOPHILIA AND OTHER CONGENITAL COAGULOPATHIESThe physiology of hemostasisSierra, Cristina; Moreno, Maite; García-Ruiz, Juan C. Author Information Cruces University Hospital, Barakaldo, Spain Correspondence to Cristina Sierra, MD, Cruces University Hospital. Plaza de Cruces s/n. 48.903. Barakaldo (Spain) E-mail: [email protected] Received 6 April, 2021 Revised 6 October, 2021 Accepted 2 November, 2021 Blood Coagulation & Fibrinolysis: January 2022 - Volume 33 - Issue - p S1-S2 doi: 10.1097/MBC.0000000000001099 Buy Metrics Abstract The breakdown of vascular integrity triggers a series of reactions, initially involving a vasoconstriction phenomenon that reduces blood loss and leads to platelet plug formation under changing flow conditions. Once the platelet plug has formed, the coagulation system is activated in order to allow the formation of fibrin, which anchors the platelet plug to the vessel breach. Finally, once the damage has resolved, the fibrin is eliminated through fibrinolysis. This article explains all these regulatory mechanisms. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.