CASE REPORTSLeukocyte-platelet rich fibrin on the treatment of a large paradental cyst: a novel regenerative approachHeggendorn, Fabiano Luiza,b; Heggendorn, Christianee; Vidal, Fábiod; Silva, Gabriela Cristina de Carvalhoc; Gonçalves, Lucio Souzad; Lione, Viviane de Oliveira FreitascAuthor Information aPostgraduate Program in Dentistry (PPGO) at UNIGRANRIO bLaboratory of Biocorrosion and Biodegradation, National Institute of Technology cLaboratory of pharmaceutical bioassays, Pharmacy School, Federal University of Rio de Janeiro dPostgraduate Program in Dentistryn Estácio de Sá University, Estácio de Sá University eCEOT-Centro educacional Orofacial e terapêutico, Rio de Janeiro, Brazil Correspondence to Fabiano Luiz Heggendorn, MSc, DSc, Postgraduate Program in Dentistry (PPGO) at UNIGRANRIO, Rio de Janeiro, Brazil, Rua Prof. José de Souza Herdy, 1.160, bloco C, 2° andar – 25 de Agosto – Duque de Caxias – Rio de Janeiro. CEP 25071-202, Brazil Tel: +5521994119341; e-mail: [email protected] Received 29 October, 2020 Revised 27 January, 2021 Accepted 5 February, 2021 Blood Coagulation & Fibrinolysis: September 2021 - Volume 32 - Issue 6 - p 411-417 doi: 10.1097/MBC.0000000000001029 Buy Metrics Abstract Leukocyte-platelet rich fibrin (PRF) is an autologous biomaterial formed by platelets, cytokines, growth factors and cells imprisoned on a fibrin mesh, produced according to Choukroun's protocol. The aim of the present article was to report the use of PRF, associated with a bone substitute, on the regenerative treatment of a large bone defect resulting from the enucleation of a paradental cyst involving the posterior mandible. The treatment resulted in the maintenance of the bone volume, and radiographic evaluation showed new bone formation after 40 days, suggesting an osteogenic and osteoinductive effect. Also, the current literature was reviewed. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.