ORIGINAL ARTICLESSoluble thrombomodulin and cardiovascular disease risk factors in Japanese childrenKikuchi, Toshihiroa; Lin, Lishengb,c; Horigome, HitoshicAuthor Information aDepartment of Child Health, Graduate School of Comprehensive Human Sciences, Univeresity of Tsukkuba, Tsukuba, Japan bDepartment of Pediatric Cardiology, Ibaraki Children's Hospital, Futabadai, Mito, Japan cDepartment of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Correspondence to Lisheng Lin, MD, PhD, Department of Pediatric Cardiology, Ibaraki Children's Hospital, 3-3-1 Futabadai, Mito, Ibaraki 311-4145, Japan Tel: +81 29 254 1151; e-mail: [email protected] Received 21 July, 2020 Revised 30 December, 2020 Accepted 1 March, 2021 Blood Coagulation & Fibrinolysis: June 2021 - Volume 32 - Issue 4 - p 273-277 doi: 10.1097/MBC.0000000000001035 Buy Metrics Abstract This study aimed to establish standard reference values for soluble thrombomodulin in healthy prepubertal school-aged children and elucidate the relationship between soluble thrombomodulin levels and obesity, metabolic syndrome-associated indices, and other markers of vascular endothelial damage. The participants in this study were healthy Japanese children aged 9–10 years (315 boys and 267 girls). Blood tests for soluble thrombomodulin, leptin, fibrinogen, and general biochemical markers were performed, and the mean and 10th, 50th, and 90th percentiles for each marker were determined. Participants were divided into two groups based on their waist circumference (≥75 vs. <75 cm), and each parameter was compared between the two groups. Analyses were performed to compare subgroups with different numbers of risk factors for cardiovascular disease (CVD). We found that as CVD risk factors accumulated, the levels of total cholesterol, alanine aminotransferase, uric acid, soluble thrombomodulin, fibrinogen, and leptin were significantly elevated, whereas the level of high-density lipoprotein cholesterol significantly decreased. We determined reference values for soluble thrombomodulin in prepubertal children, and our results suggest that soluble thrombomodulin levels contribute to the latent progress of arteriosclerosis from childhood. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.