CASE REPORTSIncreased resistance to fibrinolysis activation in patients with coronavirus disease 2019: a case seriesDuque, Patricia; Chasco-Ganuza, Maite; Burgos-Santamaria, Alba; Terradillos, EstrellaAuthor Information Anesthesiology and Critical Care Department, Gregorio Marañon Hospital, Madrid, Spain Correspondence to Patricia Duque, MD, Department of Anesthesiology and Intensive Care Medicine, Gregorio Marañon Hospital, Madrid, Spain Tel: +00 34 646 664 465; e-mail: [email protected] Received 27 June, 2020 Revised 25 November, 2020 Accepted 8 January, 2021 Blood Coagulation & Fibrinolysis: June 2021 - Volume 32 - Issue 4 - p 298-301 doi: 10.1097/MBC.0000000000001017 Buy Metrics Abstract We describe seven critically ill and seven noncritically ill patients with coronavirus disease 2019 infection. Two viscoelastic assays were performed with ClotPro technology, activated by extrinsic system test and recombinant tissue plasminogen activator challenge test. Coagulation profile presents a marked hypercoagulability with increased resistance to fibrinolysis, reflected by tissue plasminogen activator test. Our pathological observations show that the hypercoagulative status described in these patients is, at least partially, secondary to fibrinolysis shutdown. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.