REVIEW ARTICLEBlood biocompatibility enhancement of biomaterials by heparin immobilization: a reviewPatel, HimanshuAuthor Information Department of Applied Science and Humanities, Pacific School of Engineering, Surat, Gujarat Correspondence to Himanshu Patel, Department of Applied Science and Humanities, Pacific School of Engineering, Kadodara Palsana Road (NH-8), V: Sanki, Ta. Palsana, Surat 394305, Gujarat Tel: +91 261 2772233; mobile: +91 9904408835; e-mail: [email protected] Received 25 August, 2020 Revised 10 November, 2020 Accepted 2 December, 2020 Blood Coagulation & Fibrinolysis: June 2021 - Volume 32 - Issue 4 - p 237-247 doi: 10.1097/MBC.0000000000001011 Buy SDC Metrics Abstract Blood contacting materials are concerned with biocompatibility including thrombus formation, decrease blood coagulation time, hematology, activation of complement system, platelet aggression. Interestingly, recent research suggests that biocompatibility is increasing by incorporating various materials including heparin using different methods. Basic of heparin including uses and complications was mentioned, in which burst release of heparin is major issue. To minimize the problem of biocompatibility and unpredictable heparin release, present review article potentially reviews the reported work and investigates the various immobilization methods of heparin onto biomaterials, such as polymers, metals, and alloys. Detailed explanation of different immobilization methods through different intermediates, activation, incubation method, plasma treatment, irradiations and other methods are also discussed, in which immobilization through intermediates is the most exploitable method. In addition to biocompatibility, other required properties of biomaterials like mechanical and corrosion resistance properties that increase by attachment of heparin are reviewed and discussed in this article. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.