SHORT COMMUNICATIONSIsovolemic filter-based therapeutic plasma-exchange with fresh frozen plasma is associated with minimal thromboelastometric changes in noncoagulopathic patientsPopescu, Mihaia,b; Marcu, Alexandrab; Dinca, Alexandrub; Tanase, Andreeab; Tomescu, Danaa,bAuthor Information aDepartment of Anaesthesia and Critical Care, ‘Carol Davila’ University of Medicine and Pharmacy bDepartment of Anaesthesia and Critical Care III, Fundeni Clinical Institute, Bucharest, Romania Correspondence to Mihai Popescu, MD, PhD, DESA, Department of Anaesthesiology and Critical Care, Fundeni Clinical Institute, Bucharest 022328, Romania Tel: +40 751075995; e-mail: [email protected] Received 17 August, 2020 Revised 8 October, 2020 Accepted 11 October, 2020 Blood Coagulation & Fibrinolysis: April 2021 - Volume 32 - Issue 3 - p 216-220 doi: 10.1097/MBC.0000000000000976 Buy Metrics Abstract The aim of this study was to assess the effects of isovolemic therapeutic plasma-exchange using fresh frozen plasma on coagulations parameters assessed by standard coagulation tests and rotational thromboelastometry in noncoagulopathic patients. Twenty patients who underwent isovolemic filter-based therapeutic plasma-exchange of approximately 1.5 plasma volume per session were included in the current study. Standard coagulation tests and rotational thromboelastometry (ExTEM, InTEM, FibTEM and ApTEM) were performed 30 min before and after the procedure. Isovolemic therapeutic plasma-exchange was associated with decreased fibrinogen levels (P = 0.01). Thromboelastometric assay demonstrated an increased clotting time in both ExTEM (P = 0.03) and InTEM (P = 0.01) and a decreased thrombodynamic potential index in ExTEM (P = 0.03). No significant difference in FibTEM maximum clot firmness was recorded (P = 0.41). Therapeutic plasma-exchange in noncoagulopathic patients is associated with minimal changes in thromboelastometric parameters, mainly by an increase in clotting time in both intrinsic and extrinsic pathways. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.