CASE REPORTSevere hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in childrenTchidjou, Hyppolite Kuekoua; Caron, Fiorellab; Ferec, Adelinea; Braun, Karinec; Hery, Loicb; Castelain, Sandrined; Romeo, BernardaAuthor Information aPediatric Emergency Services bDepartment of Pediatric Neurology cDepartment of Pediatrics dDepartment of Microbiology, University Hospital of Amiens-Picardie, Amiens, France Correspondence to Hyppolite Kuekou Tchidjou, MD, PhD, Pediatric Emergency Services, University Hospital of Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80054 Amiens, France Tel: +33 322087550; fax: +33 322089665; e-mail: [email protected] Received 5 July, 2020 Revised 5 August, 2020 Accepted 16 August, 2020 Blood Coagulation & Fibrinolysis: December 2020 - Volume 31 - Issue 8 - p 575-577 doi: 10.1097/MBC.0000000000000954 Buy Metrics Abstract It is now known that SARS-CoV-2 infection because of coronavirus is highly contagious and caused varying degrees of illness throughout the world. Hepatic dysfunction and the slight elevation of liver enzymes have been reported in cases of COVID-19 infection. Transient hyperphosphatasemia is a benign condition characterized by the elevation of serum alkaline phosphatase and the return to normal levels within weeks or months of first observation. We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. Given the hepatic tropism and COVID-19-related hyperinflammatory reactions, our case suggests that, an isolated severe hyperphosphatasemia in children with SARS-CoV-2 infection should increase the possibility of transient hyperphosphatasemia, even if is also demonstrated a classic natural history of the transient hyperphosphatasemia during viral infection, especially in SARS-CoV-2 infection. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.