ORIGINAL ARTICLESThe predictive value of stress hyperglycemia on thrombus burden in nondiabetic patients with ST-segment elevation myocardial infarctionSigirci, Serhat; Yildiz, Süleyman S.; Keskin, Kudret; Cetinkal, Gokhan; Aksan, Gokhan; Gürdal, Ahmet; Çetin, Şükrü; Kilci, Hakan; Kilickesmez, Kadriye O.*Author Information Department of Cardiology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey Correspondence to Serhat Sigirci, Cardiologist, Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, Sisli, 34377 Istanbul, Turkey Tel: +00 90 555 636 8034; fax: +00 90 212 224 0772; e-mail: email@example.com Received 26 March, 2019 Revised 29 May, 2019 Accepted 10 June, 2019 Blood Coagulation & Fibrinolysis: September 2019 - Volume 30 - Issue 6 - p 270-276 doi: 10.1097/MBC.0000000000000832 Buy Metrics Abstract It is established that hyperglycemia directly effects the platelet functions and fibrin structure. In this study, we aimed to investigate the predictive value of hyperglycemia on thrombus burden in nondiabetic patients with ST-segment elevation myocardial infarction (STEMI) who underwent to primer percutaneous coronary intervention (PPCI). We enrolled 619 nondiabetic patients with STEMI who received PPCI. Patients were divided two groups according to thrombus burden. Stress hyperglycemia was determined as blood glucose concentration more than 180 mg/dl and angiographic coronary thrombus burden was scored based on thrombolysis in myocardial infarction thrombus grades. Patients with thrombus grades 4 were defined as large thrombus burden (LTB), patients with thrombus burden less than thrombus grades 4 were defined as small thrombus burden. A total of 68 (11.0%) STEMI patients had stress hyperglycemia, while 223 (36.0%) patients had LTB. Sex, the prevalence of hypertension, smoking, and dyslipidemia were not different between the thrombus burden groups (P > 0.05 for all parameters). Compared with the patients with small thrombus burden, the patients with LTB were had significantly higher admission blood glucose concentrations (135 ± 39.1 mg/dl vs. 145.9 ± 43.1, P = 0.002, respectively). The multivariate logistic regression analysis demonstrated that stress hyperglycemia is an independent predictor of LTB (odds ratio: 3.025, confidence interval 1.200–7.622, P = 0.019). Admission hyperglycemia is associated with the LTB which cause adverse cardiac outcomes. Hyperglycemia may play a role on thrombus development. Copyright © 2019 YEAR Wolters Kluwer Health, Inc. All rights reserved.