ORIGINAL ARTICLESPulmonary embolism location is associated with the co-existence of the deep venous thrombosisSane, Markus A.a; Laukkanen, Jari A.a,b,c; Granér, Marit A.d; Piirilä, Päivi L.e; Harjola, Veli-Pekkaf,g; Mustonen, Pirjo E.aAuthor Information aDepartment of Internal Medicine, Jyväskylä Central Hospital, University of Eastern Finland bDepartment of Clinical Medicine, University of Eastern Finland cFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä dHeart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital eDepartment of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki fDepartment of Emergency Medicine, University of Helsinki gDepartment of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland Correspondence to Markus A. Sane, MD, Töölönkatu 19a3 00260 Helsinki, Finland E-mail: [email protected] Received 17 December, 2018 Revised 26 March, 2019 Accepted 10 April, 2019 Blood Coagulation & Fibrinolysis: July 2019 - Volume 30 - Issue 5 - p 188-192 doi: 10.1097/MBC.0000000000000813 Buy Metrics Abstract Multiple studies have shown that in approximately half of individuals with pulmonary embolism (PE), the deep venous thrombosis (DVT) is not evident at the moment of PE diagnosis. The underlying factors and the origin of PE in these patients are not completely understood: missed DVT, embolization of DVT in its entirety, or de-novo PE being possible explanations. The aim of this study was to evaluate the differences in PE patient with or without co-existing DVT. Sixty-three consecutive PE patients were included. Whole leg bilateral Doppler compression ultrasound was performed to all patients. The PE location and extension, C-reactive protein, platelet count, hemostatic markers FV, FVIII, FXIIIa, Fibrinogen, von Willebrand factor antigen, thrombomodulin were assessed. Thorough clinical assessment including echocardiography and pulmonary function tests were performed upon arrival and seven months later. The mean age of the patients was 57 years (SD 17.3) and 33 (52%) were women. Thirty-one patients (49.2%) had co-existing DVT. The presence of DVT was associated with the proximal location of the PE (100%), whereas none of the patients (n = 10) with exclusively peripheral PE had co-existing DVT. The PE extension, the measured hemostatic and inflammatory markers or the patient characteristics did not statistically differ between patients with isolated PE and PE with co-existing DVT. In roughly half of the PE patients no DVT could be detected. The location of the PE was associated with the presence of co-existing DVT. There were no differences in the PE extension, hemostatic markers or in the patient characteristic between patients with isolated PE or PE with co-existing DVT. Copyright © 2019 YEAR Wolters Kluwer Health, Inc. All rights reserved.