REVIEW ARTICLEGlobal prevalence of prothrombin gene mutation G20210A and implications in women's health a systematic reviewDziadosz, Margaret; Baxi, Laxmi V. Author Information Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, New York University Langone Medical Center, New York, New York, USA Correspondence to Margaret Dziadosz, MD, New York University Langone Medical Center, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, 550 1st Ave, New York, NY 10016, USA E-mail: [email protected] Received 17 December, 2015 Revised 18 February, 2016 Accepted 26 February, 2016 Blood Coagulation & Fibrinolysis: July 2016 - Volume 27 - Issue 5 - p 481-489 doi: 10.1097/MBC.0000000000000562 Buy Metrics Abstract Distribution of hereditary thrombophilic gene mutations differs globally. Prothrombin gene mutation G20210A is a common prothrombotic single-nucleotide polymorphism. In this systematic review, we provide a comprehensive report of the prevalence of prothrombin G20210A across the globe. Databases [Pubmed, Web of Science, Embase] were interrogated from their inception through December 2015 for articles reporting prothrombin G20210A prevalence rates and ethnicity. Prevalence rates were organized by continent and ethnoracial ancestry. A total of 113 articles were included with a total 61 876 participants tested for prothrombin G20210A. Reported prevalence rates varied from 0 to 15.9% among ethnic groups, with higher rates seen in the thromboembolism affected cohort compared with the unaffected cohort. Carrier rate distribution is supported by known historical migration patterns of global populations. This review of prothrombin G20210A prevalence may guide resourceful screening for identification of hereditary thrombophilia in female populations of interest with hypercoagulable states. Copyright © 2016 YEAR Wolters Kluwer Health, Inc. All rights reserved.