ORIGINAL ARTICLESIncremental value of hormonal therapy for deep vein thrombosis prediction an adjusted Wells score for womende Barros, Márcio Vinícius Lins; Arancibia, Ana Elisa Loyola; Costa, Ana Paula; Bueno, Fernando Brito; Martins, Marcela Aparecida Corrêa; Magalhães, Maria Cláudia; Silva, José Luiz Padilha; de Bastos, MarcosAuthor Information aEscola de Medicina, Faculdade de Saúde e Ecologia Humana, Vespasiano bDepartamento de Imagem Diagnóstica e Terapêutica, Hospital Mater Dei, Belo Horizonte cGrupo de Estudos de Medicina Tropical, Pós-Graduação em Ciências da Saúde da Faculdade de Medicina, da Universidade Federal de Minas Gerais, Minas Gerais, Brazil Correspondence to Marcos de Bastos, Rua Ceará 300 sala 201, Funcionários ZIP Code 30150.310, Belo Horizonte, Minas Gerais, Brazil E-mail: firstname.lastname@example.org Received 6 June, 2015 Revised 16 August, 2015 Accepted 22 August, 2015 Blood Coagulation & Fibrinolysis: April 2016 - Volume 27 - Issue 3 - p 328-333 doi: 10.1097/MBC.0000000000000426 Buy Metrics Abstract Deep venous thrombosis (DVT) management includes prediction rule evaluation to define standard pretest DVT probabilities in symptomatic patients. The aim of this study was to evaluate the incremental usefulness of hormonal therapy to the Wells prediction rules for DVT in women. We studied women undertaking compressive ultrasound scanning for suspected DVT. We adjusted the Wells score for DVT, taking into account the β-coefficients of the logistic regression model. Data discrimination was evaluated by the receiver operating characteristic (ROC) curve. The adjusted score calibration was assessed graphically and by the Hosmer–Lemeshow test. Reclassification tables and the net reclassification index were used for the adjusted score comparison with the Wells score for DVT. We observed 461 women including 103 DVT events. The mean age was 56 years (±21 years). The adjusted logistic regression model included hormonal therapy and six Wells prediction rules for DVT. The adjusted score weights ranged from −4 to 4. Hosmer–Lemeshow test showed a nonsignificant P value (0.69) and the calibration graph showed no differences between the expected and the observed values. The area under the ROC curve was 0.92 [95% confidence interval (CI) 0.90–0.95] for the adjusted model and 0.87 (95% CI 0.84–0.91) for the Wells score for DVT (Delong test, P value < 0.01). Net reclassification index for the adjusted score was 0.22 (95% CI 0.11–0.33, P value < 0.01). Our results suggest an incremental usefulness of hormonal therapy as an independent DVT prediction rule in women compared with the Wells score for DVT. The adjusted score must be evaluated in different populations before clinical use. Copyright © 2016 YEAR Wolters Kluwer Health, Inc. All rights reserved.