REVIEW ARTICLESThe modulation of coagulation by aptamers an up-to-date reviewHu, Piao-Pinga,b; Zhang, Kun-HeaAuthor Information aDepartment of Gastroenterology, The First Affiliated Hospital, Nanchang University bDepartment of Blood Transfusion, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China Correspondence to Kun-He Zhang, PhD, Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, China Tel: +86 791 88692507; fax: +86 791 88623153; e-mail: email@example.com Received 6 September, 2013 Accepted 15 December, 2013 Blood Coagulation & Fibrinolysis: January 2015 - Volume 26 - Issue 1 - p 1-6 doi: 10.1097/MBC.0000000000000078 Buy Metrics Abstract Coagulation and anticoagulation system is kept in balance by the orchestrated action of a variety of biological factors, and the disruption of this balance leads to the risk of hemorrhage or thrombosis. Oligonucleotide aptamers are single-stranded DNA (ssDNA) or RNA ligands that are synthesized in vitro and bind to target molecules through dimensional structure with high specificity and affinity, and thus represent attractive candidates for the development of agents to maintain the balance of coagulation and anticoagulation. In this review, we summarize recent progress in aptamer-based application in the modulation of coagulation. The aptamers with specific chemical and biological characteristics have great potential to be explored as agents for the treatment of blood coagulation abnormalities. Copyright © 2015 YEAR Wolters Kluwer Health, Inc. All rights reserved.