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Meta-analysis of factor V Leiden and prothrombin G20210A polymorphism in migraine

Lippi, Giuseppea; Mattiuzzi, Camillab; Cervellin, Gianfrancoc

Blood Coagulation & Fibrinolysis: January 2015 - Volume 26 - Issue 1 - p 7–12
doi: 10.1097/MBC.0000000000000188

Migraine is a frequent and disabling condition, which exhibits a substantial genetic background and is frequently associated with abnormalities of primary and secondary hemostasis. We performed a systematic literature search and a meta-analysis of available data about the potential associations between migraine and factor V (FV) Leiden or prothrombin (FII) G20210A gene polymorphism. The final number of studies included was 15 (all cross-sectional) about migraine and FV Leiden, and 12 (all cross-sectional) about migraine and FII G20210A polymorphism, with broad inter-study heterogeneity (I2, 82 and 85%). The cumulative prevalence of the FV 1691A allele was found to be similar between cases (n = 1450; 4.9%) and controls (n = 3468; 4.7%; P = 0.74). The cumulative prevalence of the FII 20210A allele was also found to be similar between cases (n = 1226; 4.2%) and controls (n = 3144; 4.5%; P = 0.59). Nevertheless, sub-analysis of studies in adults and children revealed that both polymorphisms were not associated with migraine in adults, but FV Leiden and the FII 20210A allele were approximately two-fold more prevalent in children with migraine than in those without. In conclusion, despite migraine exhibits a clear neurovascular origin and is frequently associated with thrombotic disorders, isolate thrombophilic mutations seem to play a negligible pathogenetic role in this condition in adults, whereas the increased prevalence of FV Leiden and the FII 20210A allele in children with migraine deserves further scrutiny.

aLaboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma

bService of Clinical Governance, General Hospital of Trento, Trento

cEmergency Department, Academic Hospital of Parma, Parma, Italy

Correspondence to Prof. Giuseppe Lippi, U.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, Parma 43126, Italy Tel: +0039 0521 703050\0039 0521 703791; e-mail:

Received 31 March, 2014

Revised 6 June, 2014

Accepted 20 June, 2014

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