Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. In 203 women with different placental vasculopathies, we determined the MTHFR C677T and the A1298C prevalence and their relative association to elevated homocysteine levels. The mean plasma homocysteine level was significantly higher in the pathologic groups when compared with the control group. We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications. Women with MTHFR A1298C polymorphism or elevated homocysteine levels have an increased risk of placental vasculopathies. The MTHFR A1298C mutation also had a positive impact on elevated homocysteine levels. The lack of association between the MTHFR C677T polymorphism and pregnancy morbidities needs further studies.
aLaboratory of Molecular Biology, Department of Hematology
bDepartment of Obstetrics and Gynecology, Military Hospital
cBiochemistry Laboratory, Rabta University Hospital, Tunis, Tunisia
Correspondence to Laboratory of Molecular Biology, Department of Hematology, Military Hospital, 1008 Mont Fleury, Tunis, TunisiaTel: +216 97025836; fax: +216 70762084; e-mail: firstname.lastname@example.org
Received 20 December, 2010
Revised 20 January, 2011
Accepted 24 January, 2011