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Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies

Klai, Sarraa; Fekih-Mrissa, Najibaa; El Housaini, Soniab; Kaabechi, Nazihac; Nsiri, Brahima; Rachdi, Radhouenc; Gritli, Nasredinea

Blood Coagulation & Fibrinolysis: July 2011 - Volume 22 - Issue 5 - p 374–378
doi: 10.1097/MBC.0b013e328344f80f

Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. In 203 women with different placental vasculopathies, we determined the MTHFR C677T and the A1298C prevalence and their relative association to elevated homocysteine levels. The mean plasma homocysteine level was significantly higher in the pathologic groups when compared with the control group. We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications. Women with MTHFR A1298C polymorphism or elevated homocysteine levels have an increased risk of placental vasculopathies. The MTHFR A1298C mutation also had a positive impact on elevated homocysteine levels. The lack of association between the MTHFR C677T polymorphism and pregnancy morbidities needs further studies.

aLaboratory of Molecular Biology, Department of Hematology

bDepartment of Obstetrics and Gynecology, Military Hospital

cBiochemistry Laboratory, Rabta University Hospital, Tunis, Tunisia

Correspondence to Laboratory of Molecular Biology, Department of Hematology, Military Hospital, 1008 Mont Fleury, Tunis, TunisiaTel: +216 97025836; fax: +216 70762084; e-mail:

Received 20 December, 2010

Revised 20 January, 2011

Accepted 24 January, 2011

© 2011 Lippincott Williams & Wilkins, Inc.