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Prevention of contrast-induced impairment of renal function by short-term or long-term statin therapy in patients undergoing elective coronary angiography

Acikel, Sadika; Muderrisoglu, Haldunb; Yildirir, Aylinb; Aydinalp, Alpb; Sade, Elifb; Bayraktar, Niluferc; Bal, Ugurb; Ozin, Bulentb

Blood Coagulation & Fibrinolysis: December 2010 - Volume 21 - Issue 8 - p 750–757
doi: 10.1097/MBC.0b013e32834014a4
ORIGINAL ARTICLES
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A decline in kidney function after contrast exposure is associated with a high risk of morbidity and mortality during hospitalization and over long-term periods. Several retrospective and recent prospective clinical trials have shown that statin therapy might prevent contrast-induced nephropathy in patients undergoing percutaneous coronary intervention. In this study, we aimed to assess the effects of statin therapies on renal function parameters in patients undergoing elective coronary angiography. One hundred and sixty patients undergoing elective coronary angiography were randomized equally into two groups: atorvastatin 40 mg/day group (statin started 3 days before coronary angiography) and an untreated control group. An additional 80 patients were included as a chronic statin therapy group. Serum creatinine, serum cystatin C, and glomerular filtration rate (GFR) were measured before and 48 h after coronary angiography. Cockcroft–Gault and Modification of Diet in Renal Disease (MDRD) equations were used to determine GFR. After coronary angiography, serum creatinine and GFR determined by MDRD were significantly better in patients using atorvastatin than those in controls (P = 0.002 and P = 0.004, respectively). Postprocedure serum creatinine, cystatin C, and GFR determined by MDRD were also significantly better in chronic statin therapy group than those in controls (P = 0.006, P = 0.003, and P = 0.004, respectively). There were no differences in renal function parameters between the short-term atorvastatin group and the chronic statin therapy group. Our data demonstrate that the use of short-term atorvastatin and chronic statin therapy may have a role in protecting renal function after elective coronary angiography.

aDepartment of Cardiology, Ministry of Health Dışkapı Yıldırım Beyazıt Research and Educational Hospital, Turkey

bDepartment of Cardiology, Turkey

cDepartment of Biochemistry, Baskent University Faculty of Medicine, Ankara, Turkey

Received 21 June, 2010

Revised 20 August, 2010

Accepted 24 August, 2010

Correspondence to Dr Sadik Acikel, Department of Cardiology, Ministry of Health Dışkapı Yıldırım Beyazıt Research and Educational Hospital, 06110 Ankara, Turkey Tel: +90 312 5962000; fax: +90 312 3186690; e-mail: sadik.acikel@tkd.org.tr

© 2010 Lippincott Williams & Wilkins, Inc.