ORIGINAL ARTICLESThe evaluation of interaction between red blood cells in blood coagulation by optical tweezersYang, Bor-Wena; Mu, Yu-Hongb; Huang, Kui-Tengb; Li, Zhea; Wu, Jie-Lunga; Lin, Yu-AnaAuthor Information aDepartment of Opto-Electronic System Engineering, R.O.C. bInstitute of Electrical Engineering, Minghsin University of Science and Technology, Hsinchu, Taiwan, R.O.C. Received 5 November, 2009 Revised 20 February, 2010 Accepted 25 February, 2010 Correspondence to Bor-Wen Yang, Department of Opto-Electronic System Engineering, Minghsin University of Science and Technology, Hsinchu 30401, Taiwan, R.O.C. Tel: +886 3 5593142x3382; e-mail: firstname.lastname@example.org Blood Coagulation & Fibrinolysis: September 2010 - Volume 21 - Issue 6 - p 505-510 doi: 10.1097/MBC.0b013e328339cc5d Buy Metrics Abstract To maintain the life of patients with hemophilia, apoplexy or hemorrhage, appropriate blood coagulation is crucial. To study the microscopic phenomena of blood coagulation and the therapeutic effects of blood medication, optical tweezers were applied to estimate the interaction between red blood cells in the coagulation process. By measuring minimum optical power required to trap the coagulating blood cells, the pN-scale interaction between them can be evaluated. In normal blood sample, the interaction rises in accordance with coagulation time. The addition of heparin attenuates the interaction and postpones the coagulation, whereas the addition of tranexamic acid starts the coagulation early at the beginning and allows the process completed in less time. © 2010 Lippincott Williams & Wilkins, Inc.