CASE REPORTSSpontaneous intracranial bleeding in a neonate with congenital afibrinogenemiaAtaoglu, Emela; Duru, Nilgun Sa; Celkan, Tirajeb; Civilibal, Mahmuta; Yavuz, Selda Ca; Elevli, Murata; Ayta, SemihaAuthor Information aDepartment of Pediatrics, Haseki Education and Research Hospital, Turkey bDepartment of Pediatric Hematology-Oncology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey Received 28 September, 2009 Revised 16 March, 2010 Accepted 17 March, 2010 Correspondence to Nilgun S. Duru, MD, Levazım mah. Aktaş sitesi B blok No: 14 I. Levent, Istanbul, Turkey Tel: +90 532 2564010; fax: +90 212 5896229; e-mail: email@example.com Blood Coagulation & Fibrinolysis: September 2010 - Volume 21 - Issue 6 - p 592-594 doi: 10.1097/MBC.0b013e32833a06e2 Buy Metrics Abstract Congenital afibrinogenemia, a very rare autosomal recessive coagulation disorder, is characterized by undetectable and extremely low antigen levels of fibrinogen in plasma. We report a male newborn with intracranial bleeding and diagnosed as congenital afibrinogenemia in the neonatal period. All members of the family were asymptomatic. Even though his sister and father showed extremely low fibrinogen levels, they did not have any symptoms. The most important finding of this case was a spontaneous intracranial hemorrhage at a very early stage of life. Another interesting point was the rapid resorption of this hemorrhage. © 2010 Lippincott Williams & Wilkins, Inc.