CASE REPORTSDe-novo thrombolysis for recurrent stroke in a patient with prior history of thrombolysisArsava, Ethem Murat; Topcuoglu, Mehmet AkifAuthor Information Department of Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey Received 27 December, 2009 Accepted 16 May, 2010 Correspondence to Ethem Murat Arsava, MD, Hacettepe University, Faculty of Medicine, Department of Neurology, Sıhhıye 06100, Ankara, Turkey Tel: +90 312 3051809; fax: +90 312 3093451; e-mail: firstname.lastname@example.org Blood Coagulation & Fibrinolysis: September 2010 - Volume 21 - Issue 6 - p 605-607 doi: 10.1097/MBC.0b013e32833c2b3c Buy Metrics Abstract A 67-year-old male with prior history of atrial fibrillation was admitted to our center with acute onset of aphasia. He was treated by intravenous thrombolysis. Approximately 2 years later he presented with left-sided weakness, and was again treated with intravenous tissue plasminogen activator (iv-tPA). The patient responded favorably to thrombolytics on both occasions, without significant complications and with satisfactory recovery. Although there is no apparent reason to withhold thrombolysis in stroke patients with prior history of iv-tPA treatment, experience regarding the use of repeated thrombolysis in recurrent stroke is under-reported in the literature. This study, although reflecting experience from a single case, highlights that repeated administration of iv-tPA is well tolerated in stroke patients with late recurrences and previous history of thrombolysis. © 2010 Lippincott Williams & Wilkins, Inc.