ORIGINAL ARTICLESIs opium addiction a risk factor for deep vein thrombosis? A case–control studyMasoomi, Mohammada; Ramezani, Mohammad Ab; Shahriari, Shabnamc; Shahesmaeeli, Armitac; Mirzaeepour, FatemehaAuthor Information aDepartment of Cardiology and Physiology Research Center, Kerman Medical Sciences University, Kerman, Iran bSurveillance Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran cClinical Research Office, Afzalipour Medical Center, Kerman Medical Sciences University, Kerman, Iran Received 28 March, 2009 Revised 6 May, 2009 Accepted 3 June, 2009 Correspondence to Dr Mohammad A. Ramezani, MD, MPH, Jomhoori Square, Khorram Street, Surveillance Department, Isfahan Cardiovascular Research Center, Isfahan 8187698191, Iran Tel: +989131412932; fax: +983113373435; e-mail: [email protected] Blood Coagulation & Fibrinolysis: March 2010 - Volume 21 - Issue 2 - p 109-112 doi: 10.1097/MBC.0b013e32832f2b1e Buy Metrics Abstract The objective of the present study was to investigate the association between opioid addiction and deep vein thrombosis (DVT) and whether opioid addiction is a risk factor of DVT. This case–control study was conducted in Kerman, Iran in 2008. The cases were selected among the patients hospitalized because of DVT. The controls were recruited from the same hospital from internal wards. Opioid addiction was investigated by physician's interview based on Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria. Logistic regression modeling was carried out for statistical analysis. The crude odds ratio (OR) of opioid addiction for DVT was 4.25 (95% confidence interval = 2.6–6.9). However, multivariate logistic regression analysis revealed that opioid addiction was not an independent risk factor for DVT, OR 0.56 (0.1–3). The method of opioid usage – oral or inhaled and injected – OR 6.3 (1.41–28.3) and previous surgery in the last 3 months before the study, OR 3.1 (1.36–7), were significant independent risk factors for incidence of DVT. Opiod addiction per se was not a risk factor for DVT, whereas the method of its use especially injection was found to be independent risk factor for DVT. Our results suggested the prophylactic treatment of anticoagulant for intravenous drug abuser is considerable. © 2010 Lippincott Williams & Wilkins, Inc.