ORIGINAL ARTICLESMathematical modeling of blood coagulation cascade: kinetics of intrinsic and extrinsic pathways in normal and deficient conditionsZhu, Donghui Author Information Department of Microbiology, Columbia University, New York, USA Received 17 September, 2006 Revised 21 April, 2007 Accepted 24 May, 2007 Correspondence to Donghui Zhu, Department of Microbiology, Columbia University, 701 W 168 Street, HHSC#610, New York 10032, USA Tel: +1 212 342 1399; fax: +1 212 342 1677; e-mail: [email protected] Blood Coagulation & Fibrinolysis 18(7):p 637-646, October 2007. | DOI: 10.1097/MBC.0b013e3282a167bb Buy Metrics Abstract A mathematical model has been developed to simulate the generation of thrombin through intrinsic and extrinsic pathways. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the kinetics due to a decrease or deficiency in the concentrations of coagulation proteins or their activities was studied. The model gives reasonable predictions without the adjustment of any parameter values. The calculated clotting time was approximately 44 s for the intrinsic pathway and approximately 8.6 s for the extrinsic pathway using normal protein concentrations in plasma. Various prolonged clotting times were observed in different factor-deficient disorders using this model. © 2007 Lippincott Williams & Wilkins, Inc.