ORIGINAL ARTICLESIncreased global fibrinolytic capacity as a clue for activated fibrinolysis in pre-eclampsiaSucak, Gülsan Türköza; Acar, Kadira; Sucak, Ayhanb; Kirazl, Serafettincı; Haznedar, RaufaAuthor Information aGazi University School of Medicine, Department of Hematology, Turkey bDr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Perinatology, Turkey cHacettepe University Faculty of Medicine, Hematology Laboratory, Ankara, Turkey Received 28 October, 2005 Revised 14 February, 2006 Accepted 16 February, 2006 Correspondence and requests for reprints to Kadir Acar, Sakarya mah. Cira sok. No:6/11, 06340 Altindag, Ankara, Turkey Tel: +90 312 363 5471; fax: +90 312 214 1137; e-mail: [email protected] Blood Coagulation & Fibrinolysis: July 2006 - Volume 17 - Issue 5 - p 347-352 doi: 10.1097/01.mbc.0000233364.72863.a0 Buy Metrics Abstract The aim of this study was to compare fibrinolysis in normal pregnancy and pre-eclampsia using individual markers of thrombosis and fibrinolysis with the contribution of a new parameter, global fibrinolytic capacity. Coagulation was determined with thrombin–antithrombin complex and prothrombin fragment 1+2 (F 1+2) and fibrinolysis markers. Tissue plasminogen activator, plasminogen activator inhibitor-1 and global fibrinolytic capacity were determined in 14 normal pregnancies and 29 women with pre-eclampsia. global fibrinolytic capacity was also determined in 14 age-matched healthy women. The Mann–Whitney U test and Pearson correlation test were used for statistical analysis. Thrombin–antithrombin complex, prothrombin fragment 1+2 levels, and global fibrinolytic capacity levels in pre-eclamptic women were significantly higher than in women with normal pregnancies (P < 0.05). Tissue plasminogen activator, plasminogen activator inhibitor-1 levels were also significantly higher in the pre-eclampsia group (P < 0.001 and P < 0.05 respectively). No significant correlation was found between global fibrinolytic capacity and thrombin–antithrombin complex, prothrombin fragment 1+2 levels, tissue plasminogen activator or plasminogen activator inhibitor-1 activity. Our results suggest that both thrombin formation and fibrinolysis are increased in pre-eclampsia compared with normal pregnancy. The increased global fibrinolytic capacity indicates that fibrinolysis remains preserved in pre-eclampsia. We suggest that global fibrinolytic capacity may be a useful parameter for accurately measuring in-vivo fibrinolysis globally, instead of with single parameters which may overlook the complex interactions between coagulation and fibrinolytic systems. © 2006 Lippincott Williams & Wilkins, Inc.