TECHNICAL NOTESPerformance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulationToh, Cheng Hock; Downey, ColinAuthor Information Roald Dahl Haemostasis & Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, UK. Correspondence and requests for reprints to Dr Cheng Hock Toh, Roald Dahl Haemostasis & Thrombosis Centre, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. Tel: +44 151 706 4322; fax: +44 151 706 5810; e-mail: email@example.com Received 28 May 2004 Revised 27 July 2004 Accepted 30 July 2004 Blood Coagulation & Fibrinolysis: January 2005 - Volume 16 - Issue 1 - p 69-74 Buy Abstract A template for diagnosing the non-overt phase of disseminated intravascular coagulation (DIC) has recently been proposed. However, validation of its performance and the proposal of a defining score are required. The aim was to assess feasibility of the non-overt DIC scoring template and its potential prognostic significance. Consecutive patients admitted to a university hospital intensive care unit were initially assessed over 2 months. Following this, a 12-month study examined the prognostic performance of the derived scores prospectively. Outcome parameters were overt DIC and 28-day mortality. The 2-month study, involving 66 patients and 919 time points, demonstrated practical feasibility and prognostic associations for mortality with scores of 5 and greater. The 12-month study involving 450 patients showed that the mortality rate was 29% (105 of 360) and 78% (70 of 90) for scores below 5 and scores of 5 or above, respectively. The mortality rate for overt DIC was also 78% (38 of 49). The non-overt DIC scoring template is workable and has prognostic relevance. A score of 5 and greater is recommended as diagnostic of non-overt DIC. © 2005 Lippincott Williams & Wilkins, Inc.