ORIGINAL ARTICLESAn increase of blood anti-beta2-glycoprotein I antibody in Japanese encephalitis associated with cerebral ischemiaChen, Wei H; Kao, Yi F; Liu, Jia SAuthor Information Stroke Biology Research Laboratory, Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. Correspondence and requests for reprints to Dr Jia-Shou Liu, Department of Neurology, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung 833, Taiwan. Tel: +886 7 731 7123, ext. 3399; fax: +886 7 311 2516; e-mail: email@example.com Received 11 March 2003 Revised 11 September 2003 Accepted 21 November 2003 Blood Coagulation & Fibrinolysis: January 2005 - Volume 16 - Issue 1 - p 55-59 Buy Abstract The role of humoral autoimmunity in virus-induced vascular thrombosis is still not clear. We encountered a patient who experienced cerebral ischemia in his early course of Japanese encephalitis. At the beginning, an increase of blood immunoglobulin G isotype of anti-beta2-glycoprotein I antibody, a prolonged activated partial thromboplastin time and thrombocytopenia resembling antiphospholipid antibody syndrome were found, and these abnormalities disappeared when the patient recovered later. A molecular mimicry between the T2688LRVLE in Japanese encephalitis virus and hexapeptide-TLRVYK may contribute for the patient's anti-beta2-glycoprotein I antibody generation. Therefore, an increase of procoagulative antibody, such as anti-beta2-glycoprotein I antibody, may display a crucial role for cerebral thrombosis associated with infectious pathogens such as Japanese encephalitis virus. The interaction between autoimmunity induction by infectious agents and procoagulation in the occurrence of vascular thrombosis may be more important than has been understood in previous studies. © 2005 Lippincott Williams & Wilkins, Inc.