ORIGINAL ARTICLESOn the correlation between local fibrinolytic activity in menstrual fluid and total blood loss during menstruation and effects of desmopressinEdlund, Månsa; Blombäck, Margaretab; He, ShubAuthor Information aDepartment of Women and Child Health, and bDepartment of Surgical Sciences/Coagulation Research, Karolinska Hospital, Stockholm, Sweden. Correspondence and requests for reprints to Måns Edlund, Department of Women and Child Health, Karolinska Hospital, S-171 76 Stockholm, Sweden. Tel: +46 8 517 763 32; fax: +46 8 31 81 14; e-mail: email@example.com Received 17 January 2003 Revised 4 April 2003 Accepted 7 April 2003 Blood Coagulation & Fibrinolysis: September 2003 - Volume 14 - Issue 6 - p 593-598 Buy Abstract The primary objective of this study was to investigate the correlation between fibrinolytic activity in menstrual fluid and total menstrual blood loss during menstruation. We also wanted to evaluate the influence of desmopressin nasal inhalation on the local fibrinolytic activity in menstrual fluid. Six women with objectively verified menorrhagia and six women with normal menstrual blood loss were examined. With a slender catheter introduced through the cervical canal, menstrual fluid was collected on the day in the cycle when the most intense bleeding occurred. The fibrinolytic activity in menstrual fluid was measured both as plasmin content using an amidolytic method with chromogenic substrate and with a fibrin plate method. A significant correlation between the amount of menstrual blood loss and fibrinolytic activity was found in menstrual fluid of both groups and with both methods. We could not find an increased fibrinolytic activity in menstrual fluid when the women with menorrhagia were treated with desmopressin nasal inhalation. Knowledge of the local factors influencing monthly blood loss can be valuable when searching for more effective medical treatment of menorrhagia. Apprehension that desmopressin should increase local fibrinolytic activity in menstrual fluid could not be confirmed. © 2003 Lippincott Williams & Wilkins, Inc.