Short CommunicationPrevalence of inherited thrombophilia in young thrombosis patients from the East Bohemian regionDulícuek, P.; Malý, J.; Pesuavová, L.; Pecka, M.Author Information The authors are with the Department of Hematology, University Hospital, Hradec Králové, Czech Republic. (Received 19 November 2001; revised 12 April 2002; accepted 12 April 2002) Address correspondence to MU Dr Petr Dulícuek, Ph.D., Department of Hematology, University Hospital, Hradec Králové PC 500 05, Czech Republic. Tel: (+42) 49 5833848; fax: (+42) 49 5832011; e-mail: email@example.com Blood Coagulation & Fibrinolysis: September 2002 - Volume 13 - Issue 6 - p 569-573 Buy Abstract Venous thromboembolism is a multifactorial disease that is defined by multiple interactions between genetic and environmental components. Inherited thrombophilia may result in a hypercoagulable state that causes an increased tendency to thrombosis. We assessed the prevalence of factor V Leiden, factor II 20210A, antithrombin III, protein C and protein S deficiency, and the presence of antiphospholipid syndrome among 325 thrombosis patients from the East Bohemian region with a first episode of thrombosis under the age of 45 years. The average age of the first thrombotic event was 34 years (age range, 14–45 years). These data are not known yet from this part of the Czech Republic. Factor V Leiden was found in 40%, factor II 20210A in 6%, antithrombin III deficiency in 4%, protein C deficiency in 6%, and protein S deficiency in 11% in this cohort. Lupus anticoagulant was detected in 8% and anticardiolipin antibodies in 6%. Our results confirm the usefulness of thrombophilia work-up in patients with venous thrombosis before the age of 45 years in our region. The diagnosis of inherited thrombophilia is important for further management of these patients. © 2002 Lippincott Williams & Wilkins, Inc.