Original ArticlesAlterations in platelet function during the ovarian cycleFeuring, M.; Christ, M.; Roell, A.; Schueller, P.; Losel, R.; Dempfle, C. E.; Schultz, A.; Wehling, M.Author Information M. Feuring, A. Roell, P. Schueller, R. Losel, A. Schultz and M. Wehling are with the Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany; M. Christ is with the Department of Internal Medicine and Cardiology, Philipps-University Marburg, Germany; and C. E. Dempfle is with the I. Med. Clinic, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany. (Received 17 December 2001; revised 15 March 2002; accepted 3 April 2002) Sponsorship: This study was supported by the German ‘Bundesministerium für Bildung und Forschung’ (to M.C., M.F. and A.S.; 01 EC0002). Address correspondence to Prof. Dr med. Martin Wehling, Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68135 Mannheim, Germany. Tel: (+49) 621 383 4058; fax: (+49) 621 383 2024; e-mail: [email protected] Blood Coagulation & Fibrinolysis: July 2002 - Volume 13 - Issue 5 - p 443-447 Buy Abstract Steroid hormones may profoundly influence hemostasis; for example, as discussed for hormone replacement therapy, pregnancy and, being less obvious, for the ovarian cycle. We investigated primary hemostasis parameters using a platelet function analyzer (PFA-100TM) during the follicular and luteal phases in 18 healthy young women without oral contraceptives. During the follicular phase, the mean closure time (CT) was 164.7 ± 56.7 s, and it decreased to 130.2 ± 30.6 s in collagen/epinephrine cartridges in the luteal phase (P = 0.0095). No significant difference could be found for CT values in collagen/adenosine diphosphate cartridges during the follicular phase as compared with the luteal phase (97.2 ± 24.2 s versus 89.6 ± 18.4 s, P = 0.174). Negative correlations between the CT values in collagen/epinephrine cartridges and von Willebrand factor from both phases of the cycle were found (follicular phase:r = −0.53; luteal phase:r = −0.54). Fibrinogen and fibrinogen degradation products were significantly increased in the luteal phase (2.49 ± 0.62 g/l versus 2.05 ± 0.59 g/l and 0.12 ± 014 versus 0.04 ± 0.04, P = 0.02 for both parameters) as compared with the follicular phase. No significant differences could be detected for plasminogen, plasmin–antiplasmin complex, prothrombin fragment 1 + 2 and D-dimer between the groups. This study indicates that platelet function is periodically altered during the ovarian cycle due to the influence of progesterone and estrogen on von Willebrand factor concentrations. © 2002 Lippincott Williams & Wilkins, Inc.