Original ArticlesComparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular diseaseWang, Z. Y.; Shi, J. M.; Han, Y.; Wang, Y. C.; Ruan, C. G.Author Information The authors are with Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, China. (Received 11 April 2001; revised 12 June 2001; accepted 15 June 2001) Address correspondence to Zhaoyue Wang, Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, 96 Shizi Street, Suzhou 215006, China. Tel: (+86) 512 5223637; Fax: (+86) 512 5228072; E-mail: firstname.lastname@example.org Blood Coagulation & Fibrinolysis: October 2001 - Volume 12 - Issue 7 - p 531-537 Buy Abstract Cerebrovascular disease and other vascular diseases are common complications of non-insulin-dependent diabetes mellitus (NIDDM) and are associated with its increased morbidity and mortality. Platelet activation plays an important role in the pathomechanisms of these vascular diseases. Although several indices have been used to assess platelet activation, few data are available indicating which are more sensitive or more valuable in this situation. We have measured platelet arachidonic acid metabolites [thromboxane B2 (TXB2) and 11-dehydro-thromboxane B2 (TXB2)] and plasma P-selectin, platelet fibrinogen binding and membrane glycoproteins in 47 well-characterized NIDDM patients with cerebrovascular disease, 38 NIDDM patients without vascular diseases, and 36 age-matched healthy individuals. Our study shows that platelets were remarkably activated in NIDDM patients with cerebrovascular diseases. The measurement of plasma 11-dehydro-TXB2 and the determination of fibrinogen binding to, and P-selectin expression on platelets would reveal a higher diagnostic sensitivity for detecting in vivo platelet activation than other markers. © 2001 Lippincott Williams & Wilkins, Inc.