Article: PDF OnlyIncreasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatinGottsäter, A.; Anwaar, I.; Lind, P.; Mattiasson, I.; Lindgärde, F.Author Information A. Gottsäter, I. Mattiasson and F. Lindgärde are with the Department of Vascular and Renal Diseases and I. Anwaar and P. Lind are with the Department of Medicine, University of Lund, University Hospital MAS, Malmö, Sweden. Blood Coagulation & Fibrinolysis: April 1999 - Volume 10 - Issue 3 - p 133-140 Buy Abstract Lipid-lowering statin treatment reduces cardiovascular morbidity and mortality and improves endothelial function in patients with hypercholesterolemia. The aim of the present study was to evaluate plasma levels of fibrinogen, factor VII, and the macrophage-derived inflammatory mediator neopterin during lipid lowering. In addition, the endothelial production of platelet antiaggregatory and vasodilatory factors such as nitric oxide and prostacyclin, and vasoconstrictive factors such as endothelin-1, was assessed. Plasma fibrinogen, factor VII, endothelin-1, and the neopterin and intraplatelet nitric oxide and prostacyclin mediators cyclic 3′-5′guanosine monophosphate (cGMP) and cyclic 3′-5′adenosine monophosphate (cAMP) were measured before and 6 months after the institution of treatment with fluvastatin in 17 patients (eight men and nine women, median age 60 years) with vascular disease and previously untreated hypercholesterolemia. After 6 months, a decrease of 1.62 mmol/1 [1.26–2.18 (19%); P < 0.01] was noted in levels of total cholesterol, and a decrease of 1.70 mmol/1 [1.52–2.30 (28%); P < 0.01] in levels of low-density lipoprotein cholesterol. Plasma levels of fibrinogen had increased [from 4.81 g/1 (4.26–5.27) to 5.17 g/1 (4.81–5.67); P < 0.05], whereas no significant changes had occurred in intraplatelet levels of cGMP [decrease by 0.05 pmol/109 platelets (-0.17 to 0.24); NS], cAMP [decrease by 0.13 pmol/109 platelets (-0.37 to 0.86); NS], plasma endothelin-1 [decrease by 0.05 pg/ml (-0.60 to 0.70); NS], plasma factor VII [from 1.14 IE/ml (0.58–1.38) to 1.22 IE/ml (0.96–1.46); NS], or plasma neopterin [from 8.6 nmol/1 (7.1–11.5) to 8.7 nmol/1 (7.9–11.3); NS]. In conclusion, during cholesterol-lowering treatment with fluvastatin, plasma levels of fibrinogen increased whereas intraplatelet cyclic nucleotide levels and plasma endothelin-1, factor VII and neopterin levels were unchanged. © 1999 Lippincott Williams & Wilkins, Inc.