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Amiral J.; Lormeau, J. C.; Marfaing-Koka, A.; Vissac, A. M.; Wolf, M.; Boyer-Neumann, C.; Tardy, B.; Herbert, J. M.; Meyer, D.
Blood Coagulation & Fibrinolysis: March 1997
Review Paper: PDF Only
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New carbohydrate-based anticoagulants devoid of the side effects of unfractionated heparin are currently under development and show a major potential for patients with heparin-induced thrombocytopenia (HIT) who still require efficient antithrombotic therapy. As HIT is usually associated with antibodies to heparin-platelet factor 4 (H-PF4) complexes, cross-reactivity of the heparin pentasaccharide SR90107A/ORG31540 was tested in the presence of PF4 with the plasma from 49 patients with HIT. No cross-reactivity was observed whatever the pentasaccharide concentrations. Although more extensive studies are required for excluding its total absence of immunogenicity and pathogenicity, this pentasaccharide is a candidate for use in emergency situations in patients with HIT.

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