Article: PDF OnlyDouble bolus administration of the novel recombinant plasminogen activator BM 06.022 improves coronary blood flow after reperfusion in a canine model of coronary thrombosisMartin, U.; Sponer, G.; König, R.; Smolarz, A.; Meyer-Sabellek, W.; Strein, K.Author Information U. Martin, G. Sponer and K. Strein are with the Department of Pharmacology and R. König, A. Smolarz and W. Meyer-Sabellek are with the Department of Clinical Research, Boebringer Mannheim GmbH, Sandhoferstraße 116, D-6800 Mannheim 31, Germany. Blood Coagulation & Fibrinolysis: April 1992 - Volume 3 - Issue 2 - p 139-148 Buy Abstract Reocclusion of coronary arteries is a major problem after successful thrombolysis in patients with acute myocardial infarction. We evaluated in a canine model of coronary thrombosis which is known to elicit reocclusion, whether an increased single i.v. bolus dose or two boli of the novel t-PA. variant BM 06.022 improved coronary blood flow after reperfusion compared to i.v. injection of a standard single dose of BM 06.022. Double bolus administration, but not an increased single bolus dose of BM 06.022 significantly increased the maximum achieved coronary blood flow, prolonged the cumulative patency time, maintained blood flow at the end of the experiments, and reduced residual thrombus wet weight. Thus, double bolus administration improves coronary blood flow after reperfusion in the dog. © Lippincott-Raven Publishers.