Short Communication: PDF OnlyWhole blood granulocyte aggregation in vitro in dialysis-dependent patientsTaylor, J. E.; Bridges, A.; Henderson, I. S.; Stewart, W. K.; Belch, J. J. F.Author Information J. E. Taylor, I. S. Henderson and W. K. Stewart are with the Rend Unit, and A. Bridges and J. j. F. Belch are with the Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland. Blood Coagulation & Fibrinolysis: December 1991 - Volume 2 - Issue 6 - p 765-770 Buy Abstract Whole blood granulocyte aggregation in vitro was measured in 17 hemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P< 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P< 0.01). [CAPD patients, median (range): 56.5 (44–71)%; HD patients: 53.0 (32–67)%; Controls: 42.5 (33–56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be one of many factors contributing to their increased cardiovascular morbidity. © Lippincott-Raven Publishers.